Nomenclature phenyl substituted

More recently, Bayer disclosed potent, selective PDE2 inhibitors in a series of patents (Figure 9.34) [121]. A key feature of these inhibitors, which belong to the substrate-analog series, is a benzylic rather than a phenylic substitution at position 2 (using the common numbering system of purine nomenclature) of the heterocycle. Thus, inhibitors 145 and 146 demonstrated moderate potency toward PDE2 and... 

In I.U.P.A.C. nomenclature, the group—C5H5 derived by removing one hydrogen from benzene, is called the phenyl group. An aromatic hydrocarbon with an aliphatic side chain is named as a phenyl substituted hydrocarbon. Eor example ... 

Solution This problem requires a knowledge of arene nomenclature. Benzene (CeHe) is the simplest aromatic hydrocarbon. Benzene compounds can be named as a derivative of benzene or as a phenyl-substituted compound. 

Here again a note on nomenclature is needed. If compounds of type 25 are considered as substituted phosphoranes, names such as the one given above are appropriate. If, on the other hand, their heterocyclic nature stays in the foreground, the correct names (as used by Chemical Abstracts) are such as 5-phenyl-5,5 -spirobi[5H-dibenzophosphole]. Both naming procedures are consistent with IUPAC rules and are applicable to similar arsenic, antimony- and bismuth-heterocycles as well (see later chapters). 

Heterocycle (85) may be systematically described as 3-substituted anhydro-5-hydroxy-1,2,3,4-oxatriazolium hydroxide. However, this nomenclature is somewhat cumbersome and the terminology mesoionic has been used throughout this review. Thus compounds (85)-(87) and (91) are named mesoionic l,2,3,4-oxatriazol-5-ones (85), -5-thiones (86), -5-imines (87) and mesoionic l,2,3,4-thiatriazole-5-alkenes (91), respectively. Using IUPAC Rule. C-87 (85) is named 3-substituted l,2,3,4-oxatriazol-5-ylio oxide or 3-substituted l,2,3,4-oxathiazolylium-5-olate and (87 R = R1 = Ph) is named iV-[3-phenyl-5-(l,2,3,4-oxatriazolio)]anilide. 

Nomenclature is always a vexing subject the ligand (Fig. 1) has been known variously as 2,2, 2"-tripyridyl, 2,2, 2"-tripyridine, 2,6 -bis(2-pyridyl)-pyridine, and 2,2 6, 2"-terpyridine. The latter is the systematic name (262) and will be used throughout this article. All other compounds will be named systematically, according to lUPAC recommendation A-54. In this article, the abbreviations terpy, quaterpy, quinquepy, bipy, and phen will be used for the ligands in Figs. 1-5, respectively. Substituted derivatives will not be similarly described thus 4,4"-diethyl-4 -phenyl-2,2 6, 2"-terpyridine (Fig. 6) will be denoted 4,4"-Et2-4 -Phterpy. 

The name in Example 4 regards the compound as derived from arsonic acid, by substitution of a phenyl group for the hydrogen atom bound directly to arsenic. The name in Example 5, in addition to the hydrogen substitution, involves functional replacement nomenclature (Section IR-8.6). 

Esters (4.48) have one carbon substituent at the carbonyl and one -OR group. They are formed from acids and alcohols (Figure 4.11), and the name of the ester is a combination of the acid and alcohol names. The name of the alcohol used the form of a substituent, methyl, ethyl, phenyl, etc., and the acid part now takes the suffix -oate, to indicate the ester functionality. Thus 4.49 is methyl propanoate. The most common error that students make in naming esters is that they don t recognize the functional group and try to name them as substituted ketones. If you are finding the nomenclature of these difficult, it s often helpful to separate the ester into the acid and alcohol from which it was made. 4.50 was made from ethanoic (acetic) acid and 1-penta-nol hence, the name is 1-pentyl ethanoate or 1-pentyl acetate. In text, esters may be written as... 

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