Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Nociceptive stimuli

Psychotic disorders Cautiously treat patients suffering from psychotic disorders, schizophrenia, or confusional states and keep under careful surveillance because exacerbations of these conditions have been observed with oral administration. Autonomic dysreflexia Use with caution in patients with a history of autonomic dysreflexia. The presence of nociceptive stimuli or abrupt withdrawal may cause an autonomic dysreflexic episode. [Pg.1283]

Arendtnielsen L, Petersenfelix S, Fischer M, et al (1995) The effect of N-methyl-o-aspartate antagonist (ketamine) on single and repeated nociceptive stimuli a placebo-controlled experimental human study. Anesth Analg 81 63-68 Areosa SA, Sherriff F (2003) Memantine for dementia (Cochrane Review). Cochrane Database Syst Rev 1 CD003154... [Pg.285]

Cells in the substantia gelatinosa (lamina II contains highest levels of opioid binding) of the dorsal horn of the spinal cord respond to incoming nociceptive stimuli and regulate, or gate, the transmission of nociceptive impulses to other pathways within the CNS via the... [Pg.311]

Opioid binding at medullary sites is consistent with the respiratory depressant effects of the drugs. Binding in the nucleus accumbens and the resultant release of dopamine by the /x- and 8-opioids is linked to the development of physical dependence. However, the K-opioids, which also bind extensively in the nucleus accumbens, are linked to a decrease in dopamine release, possibly explaining their lower abuse liability. The localization of different receptor subtypes within different-size fiber pathways has been established. The x- and 8-receptors appear associated with the large-diameter fibers, while the K-receptors appear to be located in the small to medium-size fiber bundles of the dorsal root ganglia. Such differences may explain the modulation of specific types of nociceptive stimuli by the different opioid agonists and opioid peptides. [Pg.318]

Wake, K., Yamazaki, H., Hanzawa, S., Konno, R., Sakio, H., Niwa, A., Hori, Y. Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase, Neurosci. Lett. 2001, 297, 25-28. [Pg.427]

The NE system plays an important role in the perception, modulation, and response to the pain. Nociceptive stimuli arrive into the LC via the PGI pathway. NE neurons respond to the nociceptive stimuli by burst firing followed by silence (Dremencov et al., 2007a Dremencov et al., 2007c Szabo and Blier 2001b Szabo and Blier 2001d Szabo and Blier 2001g Szabo... [Pg.367]

These findings might be explained by the observation that 5-HT3A-R are expressed mostly on myelinated A5 afferents and a unique population of C fibers, few of which coexpress the vanilloid/capsaicin receptor VR1 or the proedema factor substance P (137). Consistent with this expression pattern, deep dorsal hom neurons in the KOs fire at a lower rate than those of control animals during exposure to nociceptive stimuli. [Pg.551]

Activity profiles of pethidine and a-prodine against different nociceptive stimuli in mice and rats classify these 4 phenylpiperidines as /x-receptor agonists typified by morphine. ... [Pg.275]

Fig. 175. Correspondence between the classical three-zonal subdivision of the cerebellum of Brodal (1940 upper panel), the sagittal projection zones of the spino-olivocerebellar climbing fiber paths of Oscarsson c.s. (middle panel) and the anatomical zones of Voogd (lower panel). Arrows indicate the transverse branching of climbing fibers between zones (Ekerot and Larson, 1982). Hatched zones receive short-latency input from the DF-SOCP (Ekerot and Larson, 1979a) and are activated by nociceptive stimuli. Garwicz et al. (1992) in Garwicz (1992). Fig. 175. Correspondence between the classical three-zonal subdivision of the cerebellum of Brodal (1940 upper panel), the sagittal projection zones of the spino-olivocerebellar climbing fiber paths of Oscarsson c.s. (middle panel) and the anatomical zones of Voogd (lower panel). Arrows indicate the transverse branching of climbing fibers between zones (Ekerot and Larson, 1982). Hatched zones receive short-latency input from the DF-SOCP (Ekerot and Larson, 1979a) and are activated by nociceptive stimuli. Garwicz et al. (1992) in Garwicz (1992).
In addition to its central stimulation of I1-IBS and Q2-adrenoceptors (20,21), clonidine (as well as other Q2-adrenergic agonists), when administered epidurally, produces analgesia by stimulation of spinal a2-adrenoceptors, inhibiting sympathetically mediated pain pathways that are activated by nociceptive stimuli, thus preventing transmission of pain signals to the brain (9). Activation of a2-adrenoceptors also apparently stimulates acetylcholine release and inhibits... [Pg.1152]

Chemical repellents produce their effect in one of two ways (Rogers, 1974). Primary chemical repellents are congenitally avoided because of their unpleasant sensory attributes. While primary chemical repellents may be malodorous or unpalatable, most such repellents are nociceptive stimuli causing irritation and pain. Primary repellents are often mimics of pain-promoting neurochemicals, hence the basis for their congenital avoidance (Clark 1998). Secondary repellents are agents that cause illness or pain and, when paired with ancillary sensory stimuli, promote learned avoidance of treated substrates (Garcia et al., 1966). The distinction between the two types of repellents is that animals do not need to learn about primary repellents because their aversive properties are intrinsic. By definition, primary repellents can become secondary repellents, but not vice versa. [Pg.624]

Neuropathic pain is distinct from normal, nociceptive pain triggered by noxious stimuli. It is believed to be triggered by persistent nociceptive stimuli or frank nerve injury. These conditions activate a series of adaptive and, eventually, maladaptive changes in the function and properties of pain-carrying fibers and other sensory neurons, including phenotypic changes and alterations in gene expression, as well as the fundamental properties of specific neurons and sensory... [Pg.35]

AMPA receptors are a family of proteins that line sodium ion channels expressed in the brain, spinal cord, dorsal root, and periphery. These receptors transmit both sensory and nociceptive stimuli. Transmission mediated by AMPA is believed to play an important role in wind-up and central plasticity. Thus, it is an important component in persistent pain states. Antagonists of the AMPA receptor have significant analgesic potential however, the well-known side effects of ataxia and sedation have hampered their development. [Pg.432]


See other pages where Nociceptive stimuli is mentioned: [Pg.76]    [Pg.268]    [Pg.88]    [Pg.301]    [Pg.512]    [Pg.283]    [Pg.284]    [Pg.319]    [Pg.320]    [Pg.347]    [Pg.76]    [Pg.231]    [Pg.421]    [Pg.482]    [Pg.120]    [Pg.32]    [Pg.489]    [Pg.250]    [Pg.253]    [Pg.475]    [Pg.86]    [Pg.156]    [Pg.265]    [Pg.320]    [Pg.546]    [Pg.265]    [Pg.270]    [Pg.274]    [Pg.212]    [Pg.367]    [Pg.301]    [Pg.3426]    [Pg.58]   
See also in sourсe #XX -- [ Pg.353 ]




SEARCH



Nociceptive

Stimulus

© 2024 chempedia.info