NOAELs no-observed adverse effect

NOAEL = no-observable-adverse-effect level Resp = respiratory wk = week(s). 

GO) = gavage in oil (GW) = gavage in water Gd = gestation day Hemato = hematological LD50 = lethal dose, 50% kill LOAEL = lowest-observable-adverse-effect level M = male Metab = metabolic Musc/skel = musculoskeletal NOAEL = no-observable- adverse-effect level ... 

COL = cancer effect level d = days(s) hr = hour(s) LOAEL = lowest-observed-adverse-effect level mo = month(s) NOAEL = no-observed-adverse-effect level Resp = respiratory wk = week(s)... 

NOAEL (no-observed-adverse-effect level) is defined as the highest dose at which no adverse effects are observed in the most susceptible animal species. The NOAEL is used as a basis for setting human safety standards for acceptable daily intakes (ADIs), taking into account uncertainty factors for extrapolation from animals to humans and inter-individual variabilities of humans. The adequacy of any margin of safety or margin of exposure must consider the nature and quality of the available hazard identification and dose-response data and the reliability and relevance of the exposure estimations. In some cases, no adverse endpoint can be identified such as for many naturally occurring compounds that are widespread in foods. In that case, an ADI Not Specified is assigned. ... 

The quantitative measurement of toxicity level is expressed by parameters like NOEL (no observed effect level), NOAEL (no observed adverse effect level), and ADI (acceptable daily intake). The NOEL values are divided by 100 to obtain ADI values. The 100 safety factor derives from 10 x 10, where the 10s represent the animal-to-human conversion rate and the human variability factor. Currently, the most useful index of safety is the ADI, expressed as milligrams of test substance per kilogram of body weight (ppm), with the recommendation not to eat more than the ADI per day. The FDA, EU, and WHO agree on the ADI principle. 

Bd Wt = body weight Cardio = cardiovascular d = day(s) Endocr = endocrine exp. = exposure(s) F = female Gastro = gastrointestinal Hemato = hematological LOAEL = lowest-observed-adverse-effect level M = male Musc/skel = musculoskeletal NOAEL = no-observed-adverse-effect level RBC = red blood cell Resp = respiratory TAP1 = triaryl phosphate hydraulic fluid (TAP1 is similar, if not identical, to Cellulube 220) TPP = triphenyl phosphate wk = week(s) x = times. 

Abbreviation NOAEL, no-observed-adverse-effect level. 

Based on a NOAEL (no observable adverse effect level) of 400 pg Se daily, equivalent to 5.7 pg/kg BW daily for a 70-kg person. 

NOAEL No observed adverse effect level tpa Tonne per annum... 

NOAEL = no-observed-adverse-effect level ppd = post partum day(s) repro = reproductive T3 = triodothyronine wk = week(s) x = time(s) yr = year(s). 

---