Nitroglycerin buccal

Nitroglycerin Buccal Tablet Nitroguard Forest Pharmaceuticals... 

Oral mucosal membranes provide a port for systemic therapy as weU. Nitroglycerin sublingual tablets (Nitrostat) abort acute mgina attacks methyl-testosterone [58-18-4] buccal tablets (Android 5) are indicated for testosterone [58-22-0] replacement therapy (39) md nicotine [54-11-5] gum (Nicorette) aids in smoking cessation. 

Promoting an Optimal Response to Therapy N URATES The nitrates may be administered by die sublingual (under die tongue), buccal (between the cheek and gum), oral, IV, or transdermal route Nitroglycerin may be administered by die sublingual, buccal, to peal, transdermal, oral, or IV route If die buccal form of nitroglycerin has been prescribed, die nurse instructs die patient to place die buccal tablet between die cheek and gum or between die upper lip and gum above die incisors and allow it to dissolve The nurse shows the patient how and where to place die tablet in die mouth. Absorption of sublingual and buccal forms is dependent on salivary secretion. Dry mouth decreases absorption. 

Bray CL, Jain S, Faragher EB, Myers A, Myers P, MacIntyre P, Rae A, Goldman M, and Alcorn M (1991) A comparison of buccal nitroglycerin and sublingual nitroglycerin in the prophylaxis and treatment of exertional (situation-evoked) angina pectoris. Eur. Heart J. 12 Suppl A 16-20. 

NITROGLYCERIN, SUBLINGUAL Dissolve 1 tablet under tongue or in buccal pouch (between cheek and gum) at first sign of an acute anginal attack. Repeat approximately every 5 minutes until relief is obtained. Take no more than 3 tablets in 15 minutes. May be used prophylactically 5 to 10 minutes prior to activities which might precipitate an acute attack. 

Nitroglycerin is a lipid-soluble substance that is rapidly absorbed across the sublingual or buccal mucosa. Its onset of action occurs within 2 to 5 minutes, with maximal effects observed at 3 to 10 minutes. Little residual activity remains 20 to 30 minutes after sublingual administration. The plasma half-life of nitroglycerin, given... 

Certain vasodilators (like nitroglycerine) and hormones which can penetrate the buccal mucosal wall will only be kept in buccal cavity or under the tongue. It provides rapid onset of action and prevention of gastrointestinal interactions. 

Nitroglycerin, slow-release, buccal 1-2 mg per 4 hours 3-6 hours... 

Ritschel, W.A., et al. 1985. Disposition of nitroglycerin in the beagle dog after intravenous and buccal administration. Methods Find Exp Clin Pharmacol 7 307. 

Lahiri, A., et al. 1986. Buccal nitroglycerin tablets in heart failure. Ann Intern Med 105 141. 

Nitroglycerin (NTC) is distinguished by a high membrane penetrability and very low stability. It is the drug of choice in the treatment of angina pectoris attacks. For this purpose, it is administered as a spray, or in sublingual or buccal tablets for transmucosal delivery. The onset of action is between 1 and 3 minutes. Due to a nearly complete presystemic elimination, it is poorly suited for oral administration. Transdermal delivery (nitroglycerin patch) also avoids presystemic elimination. 

Nitrate therapy should be the first step in managing acute attacks of chronic stable angina if the episodes are infrequent (e.g., a few times per month). If angina occurs no more often than once every few days, then sublingual nitroglycerin tablets or spray or buccal products may be sufficient. 

Early recognition of buccal and sublingual absorption was manifested in the use of nitroglycerin by these dosage routes to treat severe headache and to relieve angina pectoris. 

Sanghera, S.S. Goldberg, A.A.J. Parson, D.F. Buccal nitroglycerin in elderly patients with congestive heart failure. Practitioner 1985, 229, 1054-1055. 

Iga, K. Ogawa, Y. Sustained-Release buccal dosage forms for nitroglycerin and isosorbide dinitrate increased bioavailability and extended time of absorption when administered to dogs. J. Controlled Release 1997, 49, 105-113. 

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