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4- Nitro toluene-2-sulfonic acid

The type of the electrochemical cell (divided or undivided) can influence the EOI values especially for the treatment of benzene derivatives containing a -NO2 substituent. A typical example is the electrochemical treatment of p-Nitro Toluene Sulfonic acid (p-NTS) low EOI values (- 0,1) were obtained in the divided cell contrary to the undivided cell where high EOI values (0,5) were obtained. The increase of EOI values in the undivided cell is due to the cathodic reduction of -NOg group to -NH2 group, this transformation promotes the electrochemical oxidation as the substituent constant (a) for -NH2 has negative value (favouring the electrophilic attack on the benzene ring) contrary to the -NO2 substituent which has positive value (see 4 i). [Pg.93]

A solution of trifluoroacetic acid in toluene was found to be advantageous for cydization of pyruvate hydrazoncs having nitro substituents[4]. p-Toluene-sulfonic acid or Amberlyst-15 in toluene has also been found to give excellent results in preparation of indole-2-carboxylale esters from pyruvate hydra-zoiies[5,6J. Acidic zeolite catalysts have been used with xylene as a solvent to convert phenylhydraziiies and ketones to indoles both in one-flask procedures and in a flow-through reactor[7]. [Pg.59]

Fig. 1 Reaction scheme for the synthesis of the 2 -0-allyluridine building block Reagents i, l,3-dichlorO l,l,3,3-tetraisopropyldisiloxane in pyridine ii, chlorotri-methylsilane, and triethylamine in 1,2-dichloroethane, iii, 2-mesitylenesulfonyl chloride, triethylamine, and 4-dimethyIaminopyndine in dichloromethane iv, 2,6-dichlorophenol, l,4-diazabicyclo[2 2.2]octane and triethylamine v, p-toluene sulfonic acid monohydrate in THF/dichloromethane, vi, allyl ethyl carbonate, l,4-bis(diphenylphosphino)butane and tris(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran, vii, tetrabutylammonium fluoride in tetrahydrofuran viii, 2-nitro-benzaldoxime and 1,1,3,3-tetramethylguanidine in acetonitrile, ix, 4,4 -dimethoxytrityl chloride and triethylamine in pyridine x, 2-cyanoethoxy M -diisopropyl-aminochlorophosphine and //,iV-diisopropylethyiamine in 1,2-dichloroethane. Fig. 1 Reaction scheme for the synthesis of the 2 -0-allyluridine building block Reagents i, l,3-dichlorO l,l,3,3-tetraisopropyldisiloxane in pyridine ii, chlorotri-methylsilane, and triethylamine in 1,2-dichloroethane, iii, 2-mesitylenesulfonyl chloride, triethylamine, and 4-dimethyIaminopyndine in dichloromethane iv, 2,6-dichlorophenol, l,4-diazabicyclo[2 2.2]octane and triethylamine v, p-toluene sulfonic acid monohydrate in THF/dichloromethane, vi, allyl ethyl carbonate, l,4-bis(diphenylphosphino)butane and tris(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran, vii, tetrabutylammonium fluoride in tetrahydrofuran viii, 2-nitro-benzaldoxime and 1,1,3,3-tetramethylguanidine in acetonitrile, ix, 4,4 -dimethoxytrityl chloride and triethylamine in pyridine x, 2-cyanoethoxy M -diisopropyl-aminochlorophosphine and //,iV-diisopropylethyiamine in 1,2-dichloroethane.
The ring-chlorinated derivatives of toluene form a group of stable, industrially important compounds. Many chlorotoluene isomers can be prepared by direct chlorination. Other chlorotoluenes are prepared by indirect routes involving the replacement of amino, hydroxyl, chlorosulfonyl, and nitro groups by chlorine and the use of substituents, such as nitro, amino, and sulfonic acid, to orient substitution followed by their removal from the ring. [Pg.52]

Can be prepd by diazotization of 6-nitro-4-amino toluene-3-sulfonic acid with K nitrite and dil sulfuric acid. It has also been isolated by... [Pg.298]

In general, aldehydes, ketones, acids, esters, and acid chlorides are all reduced to the corresponding alcohols hy this reagent. Alkyl halides are unreactive towards DIBAL. Amides are reduced to amines, while nitriles afford aldehydes upon hydrolysis of an intermediate imine. Isocyanates are also reduced to the corresponding imines. Nitro compounds are reduced to hydroxy-lamines. Disulfides are reduced to thiols, while sulfides, suhbnes, and sulfonic acids are unreactive in toluene at 0°C. Tosylates are converted quantitatively to the corresponding alkanes. Cyclic imides can be reduced to carbinol lactams. [Pg.164]

Versatile aromatic intermediates, especially in the manufacture of plant protection agents and dyestuffs, are the chlorinated toluene derivatives o- and p-chloro-toluene, benzyl chloride, and benzotrichloride, together with toluene nitro-deriva-tives. Sulfonic acids of toluene have extensive applications as surfactants. [Pg.236]

Toluene-4-sulfonic acid is used as a starting material in the production of 2-chloro-5-aminotoluene-4-sulfonic add (CLT-acid). CLT-acid is manufactured by chlorination of toluene-4-sulfonic add, transformation of 2-chlorotoluene-4-sulfonic add into 2-chloro-5-nitrotoluene-4-sulfonic acid followed by the reduction of the nitro group with iron/HCl. CLT-acid is used, for example, as a raw material in the production of Pigment Red 52 1, Pigment Red 53 1 and other metal complexes. [Pg.262]

Methyl-flci-nitro)-3-penten-2-one refluxed 4 hrs. in toluene -> 5-hydroxy-imino-3-penten-2-one (Y 67%) dissolved in 1 N NaOH, stirred and treated at 4° with hydroxylamine-O-sulfonic acid, and the product isolated after 2 hrs. 5-diazo-3-penten-2-one (Y 42%). F. e. s. T. Severin, P. Adhikary, and I. Brautigam, B. 109, 1179 (1976). [Pg.74]

Tosylmethyl isocyanide anion reacts with a,P-unsaturated esters, ketones or sulfones with loss of toluene-sulfinate. Isocyano-acetates react with a,P-unsaturated nitro-compounds with loss of nitrous acid. [Pg.314]

The nitration of active methylene compounds by the action of a nitrate ester under basic conditions has been found to be a general and convenient method for introducing a nitro group alpha to the activating group. By choosing the appropriate base-solvent system, we have been successful in applying the reaction to ketones, nitriles, amides, carboxyl esters, sulfonic esters, sul-fones, substituted toluenes, and heterocyclics. Usually the nitration under acidic conditions fails with these classes of compounds. [Pg.160]

In 1975 McCallum and Pethybridge [422] examined the behavior of strong acids, such as methane sulfonic, sulfuric, and nitric acids, in DMSO and concluded that these acids can be considered to be completely dissociated in dilute solution. Farrell, Terrier, and Schaal [267] later compared the pK s of nitroaromatics in both water and DMSO to examine the effects of solvation on these compounds. For the most part the pK s of the nitro-phenols, -anilines, -toluenes, and -diphenylamines were slightly higher in DMSO than in water, but in some cases this order was reversed. These authors concluded that these compounds undergo only very limited specific solvation in both solvents, and the charges in their anions are largely delocalized. [Pg.113]

In 1988 Reetz et al. introduced the concept of metal-free polymerization of acrylates, methacrylates and acrylonitrile [224,225]. Metal-free initiators are salts consisting of a carbanion (A ) having R4N as cationic counterions. They are synthesized by the reaction of neutral CH or NH-acidic compounds such as malonic acid esters, nitriles, sulfones, nitro-alkanes, cyclopentadiene, fluorene derivates, carbazoles and succinimide. Water is removed azeotropically using toluene. [Pg.270]

Dinitroresorcine (DNR) forms two isomers 2,4 and 4,6. Unlike in the nitration of some other aromatic molecules (toluene, phenol), it is possible to prepare practically pure dinitro isomers. The position of nitro groups in the ring depends on the reaction conditimis. The 2,4-isomer of DNR can be easily prepared by dinitrosatimi of resorcinol followed by alkaline oxidation of 2,4-dinitrosoresorcinol [8,14]. 2,4-DNR cannot be prepared by sulfonation of resorcinol followed by reaction with nitric acid (method used for phenol) because this method yields the trinitro compound. The 4,6-DNR isomer can be prepared in two ways (a) by nitration of 4,6-diacetylresorcinol and (b) directly by nitration of resorcinol using 98 % nitric acid at low temperatures (between —20 and —15 °C) [8],... [Pg.133]


See other pages where 4- Nitro toluene-2-sulfonic acid is mentioned: [Pg.35]    [Pg.225]    [Pg.235]    [Pg.63]    [Pg.17]    [Pg.289]    [Pg.147]    [Pg.74]    [Pg.377]    [Pg.74]    [Pg.223]    [Pg.1050]    [Pg.343]    [Pg.334]    [Pg.134]    [Pg.881]    [Pg.881]    [Pg.105]    [Pg.165]    [Pg.105]   
See also in sourсe #XX -- [ Pg.3 , Pg.327 ]




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Nitro sulfonation

Nitro sulfones

Nitro, acids

Nitro, acids toluenes

Nitro-toluenes

Toluene sulfonation

Toluene sulfonic acid

Toluene-4-sulfonate

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