5- Nitro- -amid

NO BF )" have also been used to cleave amides. Since only tertiary amides are cleaved by potassium r-butoxide (eq. 6), this method can be used to effect selective cleavage of tertiary amides in the presence of primary or secondary amides. " (Esters, however, are cleaved by similar conditions.) Photolytic cleavage of nitro amides (eq. 7) is discussed in a review. ... 

On treatment with gaseous HBr in organic solvents, N-nitros-amides regenerate the parent amide (equation 3) in quantitative yield (7f ) This implies that N-nitrosamide formation is reversible and explains why it is beneficial to add one mole of base... 

This far into a nitrosamine symposium it should hardly be necessary to point out that nitrosamines are technically just one of a group of Ji-nitroso compounds that also includes nitros-amides, nitrosocarbamates, nitrosoureas, etc. Or that nitrosa-table pesticides encompass all the categories just mentioned and more. Or that many diverse pesticides, including herbicides, insecticides, and fungicides have been converted to Ji-nitroso derivatives in the laboratory (a recent review contained a 3-page, probably incomplete, compilation), or that some of the Ji-nitroso compounds thus synthesized were determined to be carcinogenic in test animals or mutagenic in various assays. 

The mediated oxidations of a-nitro ketones and a-nitro amides in the presence of olefins have been studied [29]. In this work, Warsinsky and Steckhan found that the ensuing addition-cyclization sequence led to the... 

Warsinsky R, Steckhan E (1995) Oxidative free radical additions of a-nitro amides to alkenes and alkynes mediated by electrochemically regenerable manganew (HI) acetate. In Torii S (ed) Novel trends in electroorganic synthesis, Kodansha, Tokyo, pg 135 J. Chem. Soc. Perkin Trans 1 (1994) 1994 2027... 

Oxalsaure -bis-[methyl-nitro-amid] E16a, 1152 (N-Nitrier.)... 

Ether Bis-[(Formyl-methyl-ami-no)-methyl]- IV/lb, 1025 Hexansanre 6-Nitro- -amid E5, 1106... 

Amino-5-formylamino- XV/1, 166 -(methyl-nitro-amid) E5, 1196 Propan 2-Acetamino-2-methyl-1 -... 

Sulfonsaure 4-Methyl-benzol- -(methyl-nitro-amid) XI/2, 104... 

Very often reduction of an aromatic nitro compound is carried out in the presence of acetic anhydride, whereby the corresponding acetamido compound is formed. Amino amides are prepared by catalytic hydrogenation of nitro amides, e.g., 2-aminoacetanilide (90%). ... 

Several ascorbic acid derivatives were examined by Pensabene et al. (570) for their ability to inhibit nitrosation of pyrrolidine in a model system developed to simulate the lipid-aqueous-protein composition of bacon. While sodium ascorbate was quite effective in the aqueous phase, a combination of an ascorbyl ester with sodium ascorbate gave a better effect in the lipid phase (Table XX). The use of ascorbates and tocopherol as inhibitors of nitrosamine formation and oxidation in foods of the aqueous and lipid type has been reviewed by Newmark and Mergens (326). These compounds in combination could be markedly useful in preventing food contamination with nitrosamines and/or nitros-amides in cured meats such as bacon. 

Introduction of relatively weak functional groups, such as carbonyl, hydroxyl, nitro, amide, etc., in the nanochannels of PCPs would affect the monomer alignment, which may lead to precision control of stereoselectivity and regioselectivity of the resulting polymers. In particular, PCPs with either helical or chiral structures on the pore surface are of intense interest in chemistry and such porous solids are potentially useful to find applications in enantioselective sorption/separation and catalysis [34, 38 0, 42, 45]. Of considerable interest is the use of the chiral channels to affect asymmetric polymerizations such as asymmetric selective polymerization of racemic monomers as well as asymmetric polymerization of prochiral monomers, which may give helical polymer conformations. 

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