Nitric oxide clinical applications

Inhaled Nitric Oxide, Clinical Rationale and Applications... 

Steudel W, Hurford WE, Zapol WM. Inhaled nitric oxide basic biology and clinical applications. Anesthesiology 1999 91(4) 1090-121. 

Progress Toward Clinical Application of the Nitric Oxide-Releasing Diazeniumdiolates1... 

Clinical Applications of Inhaled Nitric Oxide in Children with Pulmonary Hypertension... 

By 1993 we had explored the clinical applications of inhaled nitric oxide in over 200 children with pulmonary hypertension or respiratory failure (Fig. 1). The majority of these patients suffered from pulmonary hypertensive congenital heart disease and were under 1 year of age, reflecting the bias toward early surgical repair of congenital heart defects at Children s Hospi-... 

D. Clinical Applications of Nitric Oxide Inhibitors and Donors While inhibitors of nitric oxide synthesis are of great research interest, none are currently in clinical use. Nitric oxide can be inactivated by heme, but application of this approach is in preclinical research. 

In contrast, drugs that release endogenous nitric oxide and donors of the molecule were in use long before nitric oxide was discovered and continue to be very important in clinical medicine. The cardiovascular applications of nitroprusside (Chapter 11) and the nitrates and nitrites (Chapter 12) have been discussed. The treatments of preeclampsia and of pulmonary hypertension and acute respiratory distress syndrome are currently under clinical investigation. Early results from the pulmonary disease studies appear promising, and one preparation of nitric oxide gas (INOmax) has been approved for use in neonates with hypoxic respiratory failure. 

Justino CIL, Rocha-Santos TA, Duarte AC, Rocha-Santos TA (2010) Review of analytical figures of merit of sensors and biosensors in clinical applications. Trends Anal Chem 29(10) 172-1183 Keefe MK, Benkstein KD, Hup JT (2000) Luminescent sensor molecules based on coordinated metals a review of recent developments. Coord Chem Rev 205(l) 201-228 Kharitonov SA, Barnes PJ (2000) CUnical aspects of exhaled nitric oxide. Eur Respir J 16 781-792 King WH Jr (1964) Piezoelectric sorption detector. Anal Chem 36 1735-1739... 

Keefer, L.K. (2003). Progress toward clinical application of the nitric oxide-releasing diazenium-diolates. Annu. Rev. Pharmacol. Toxicol. 43, 585-607. 

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