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Nitric Oxide and Central Nervous System Diseases

General Overview-Gaining Control over Various NOS Enzymes that Concurrently Contribute to Degenerative CNS Diseases [Pg.347]

All three isoforms can diverge from their functional regulatory roles and during disease states contribute to NO mediated pathologies of the CNS. Excessive accu- [Pg.347]

the conversion of NO to neurotoxic species or 4. block downstream cell signaling systems involved with NO-mediated apoptosis and necrosis. [Pg.348]

Nitric Oxide and Central Nervous System Diseases... [Pg.347]

Nitric oxide (NO) displays potent activities in the cardiovascular system as well as in the central and peripheral nervous systems. NO and its co-product L-citruUine are produced by the oxidation of L-arginine (28) by nitric oxide synthase (NOS) (Scheme 13.4). Selective modulation of NO biosynthesis offers the opportunity for therapeutic intervention of neurodegenerative diseases, among others. Based on the mechanism proposed for NO biosynthesis, two boronic acid analogues (29 and 30, Figure 13.7) of... [Pg.492]

See other pages where Nitric Oxide and Central Nervous System Diseases is mentioned: [Pg.406]    [Pg.433]    [Pg.347]    [Pg.177]    [Pg.140]    [Pg.359]    [Pg.532]    [Pg.393]    [Pg.311]    [Pg.190]   


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And nervous system

Central diseases

Central nervous system , and

Central nervous system diseases

Nervous system diseases

Oxidation systems

Oxidative systems

Oxide systems

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