Nitrates gastrointestinal effects

Gastrointestinal Effects. Abdominal pain has also been reported by workers exposed to silver nitrate and oxide in the workplace (Rosenman et al. 1979). The pain was described as "burning in quality and relieved by antacids" and was reported in 10 out of 30 workers examined. Exposure levels were estimated to be between 0.039 and 0.378 mg silver/m. No information on chemical form or particle size was provided. Duration of employment ranged from less than one, to greater than ten years. 

G) = gavage Cardio = cardiovascular (F) = food Gastro = gastrointestinal Hemato = hematological LOAEL = lowest-observed-adverse-effect level NOAEL = no-observed-adverse-effect level Resp = respiratory ThN03 = thorium nitrate (W) = water. 

Lanas A, Bajador E, Serrano P, Arroyo M, Fuentes J, Santolaria S. Effects of nitrate and prophylactic aspirin on upper gastrointestinal bleeding a retrospective case-control study. J Int Med Res 1998 26(3) 120-8. 

Other organs Nitrates relax the smooth muscle of the bronchi, gastrointestinal tract, and genitourinary tract, but these effects are too small to be clinically useful. Intravenous nitroglycerin (sometimes used in unstable angina) reduces platelet aggregation. There are no significant effects on other tissues. 

Table 27 2J. Sulfpes in excessive amounts cause an osmotic catharsis resulting in mild to moderate diarrhea that is usually transient and appears similar to the osmotic effect of excessive total dissolved solids (IDS). Calcium and magnesium cause no clinical effects in the cOncentrPions found in water. Iron at the usual concentrations in wper causes esthetic and, possibly, nutritional effects, but does not affect the gastrointestinal tract. Nitrate causes methemoglobinemia, not diarrhea.

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