Nicotinyl alcohol

Therapeutic Function Peripheral vasodilator Chemical Name 3-pyridinemethanol Common Name 3-pyridylcarbinol Structural Formula  

The catalyst is prepared by suspending 5 kg of catalyst grade charcoal in 200 liters of water, in a pressure vessel, and adding thereto 25 liters of 4% (as Pd metal) aqueous palladous chloride. Air is displaced from the vessel and then hydrogen is passed into the aqueous mixture at a pressure of 3 to 5 psi, while stirring, until no further absorption is noted and the chloride is completely reduced to metal. 

To the aqueous suspension of the palladized charcoal catalyst thus obtained are added 20.8 kg of 3-cyano-pyridine (96% purity) and then are added 70 liters of a hydrochloric acid solution prepared by diluting 30 liters of 36% HCI with 40 liters of water. This represents approximately 1.75 mols of HCI for each mol of 3-cyano-pyridine. The suspension is maintained at 10° to 15°C and stirred continuously while introducing a current of hydrogen at a pressure of 3 to 5 psi. When absorption of hydrogen ceases and the 3-cyano-pyridine is completely reduced, the reaction mixture is filtered to remove the catalyst. 

The filter cake is washed with 40 liters of water in two equal portions, and the wash water Is added to the filtrate. 

The combined liquors, which comprise an aqueous hydrochloric acid solution of 3-amino-methyl-pyridine hydrochloride, are then heated to a temperature of 60° to 65°C, and ethyl nitrite gas is passed into the heated solution. The ethyl nitrite is generated by placing 20 liters of 90% ethyl alcohol in a suitable vessel, diluting with 200 iiters of water, and, while stirring, adding to the dilute alcohol 18.3 kg of nitrosyl chloride at the rate of 2.25 kg per hour. (The process using methyl nitrite is carried out by substituting a stoichiometrically equivalent quantity of methyl alcohol for the ethyl alcohol.) 

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Nicotinyl alcohol (3-pyridinylcarbinol, 3-pyridinemethanol) (27) has use as an antilipemic and peripheral vasodilator. It is available from either the reductions of nicotinic acid esters or preferably, the reduction of the nitrile to the amine followed by dia2otation and nucleophilic displacement. It is frequently adininistered in the form of the tartrate (Eig. 7). Nicotinic acid is frequently used as a salt in conjunction with basic dmgs such as the peripheral vasodilator xanthinol niacinate (28). Nicotinic acid and its derivatives have widespread use as antihyperlipidemic agents and peripheral vasodilators (1). 

Isoxsuprine Minoxidil Nicotinyl Alcohol Nylidrin Tolazoline... 

CJH4N2 100-54-9) see Nicotinamide Nicotinyl alcohol nicotinoyl chloride... 

Neurotransmitters, in regulation of blood pressure, 55 Nialamide, 254 Nicotinic acid, 253 Nicotinyl alcohol, 253 Nidroxyzone, 228 Nifenazone, 234 Niflvminic acid, 256 Nifurprazine, 231 Nikethamide, 253 Nitrazepam, 366 Nitrimidazine, 240 Nitrofurantoin, 230 Nitrofuratel, 229 Nitrofurazone, 228 5-Nitrofurfural, 228 Nitrofuroxime, 228 Nitrosation... 

Nicotinic acid derivatives include acipimox, aluminium nicotinate, nicotinyl alcohol, and xanthinol nicotinate. The adverse effects of these compounds appear to be identical to those of nicotinic acid. 

Late adverse effects include hepatic dysfunction, with altered liver function tests and hyperbilirubinemia. After prolonged use of nicotinic acid and nicotinyl alcohol, histological changes, for example parenchymal cell injury, portal fibrosis, cholangitis, cholestasis, biliary casts, and lymphocytic infiltrations around the bile ducts, have occasionally been seen. 

Gas Chromatography. System GA—nicotinyl alcohol RI 1215, nicotinic acid RI 1335. 

Dose. The equivalent of 100 to 200 mg of nicotinyl alcohol daily up to 600 mg daily given as a sustained-release preparation. 

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