Nicotinic cholinergic

Nicotinic Receptor Agonists. There has been significant activity in the development of muscarinic cholinergic receptor agonists for dementia. In addition, agents that interact with nicotinic cholinergic receptors may also have therapeutic value. Nicotinic receptors have been reported to be... [Pg.99]

Pidoplichko, V.I., Noguchi, J., Areola, O.O. et al. Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction. Learn. Mem. 11 60, 2004. [Pg.33]

Isoreceptors Different receptor proteins that recognise and bind the same neurotransmitter (e.g., muscarinic and nicotinic cholinergic receptors). [Pg.244]

Muscle-relaxant A drug that relaxes skeletal (voluntary) muscle either directly by blocking nicotinic cholinergic receptors or indirectly through the activation of inhibitory spinal cord interneurons. [Pg.245]

Elgoyhen, A., Vetter, D., Katz, E. etal. Alpha 10 a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proc. Natl Acad. Sci. U.S.A. 98,3501-3506, 2001. [Pg.209]

Acetylcholine. Most of the acetylcholine in the basal ganglia is found in the striatum, as the neurotransmitter of the large spiny interneurons, which account for about 3% of all striatal neurons. Both muscarinic and nicotinic cholinergic receptors are found in the striatum. Postsynaptic muscarinic receptors may inhibit transmitter release from... [Pg.764]

Spinella M, Schaeffer LA, Bodnar RJ. (1997). Ventral medullary mediation of mesencephalic morphine analgesia by muscarinic and nicotinic cholinergic receptor antagonists in rats. Analgesia. 3 119-30. [Pg.531]

The Road to Discovery of Neuronal Nicotinic Cholinergic Receptor Subtypes... [Pg.85]

Abstract The discovery that mammalian brain expresses the mRNAs for nine different nicotinic cholinergic receptor subunits (a2-a7, p2-p4) that form functional receptors when expressed in Xenopus laevis oocytes suggests that many different types of nicotinic cholinergic receptors (nAChRs) might be expressed in the mammalian brain,. Using an historical approach, this chapter reviews some of the... [Pg.85]

Elgoyhen AB, Vetter DE, Katz E, RotWinCV, Heinemann SF, Boulter J (2001) alO a determinant of nicotinic cholinergic receptor function in mammalian vestibular and chochlear mechanosen-sory hair cells. Proc Natl Acad Sci 98 3501-3506 Fabian-Fine R, Skehel P, Erington ML, Davies HA, Sher E, Stewart MG, Fine A (2001) Ultra-structural distribution of the a7 nicotinic acetylcholine receptor subunit in rat hippocampus. J Neurosci 21 7993-8003... [Pg.107]

HoughtUng RA, Davila-Garcia Ml, Kellar KJ (1995) Characterization of (+/—)(—)[ H] epiba-tidine binding to nicotinic cholinergic receptors in rat and human brain. Mol Pharmacol 48 280-287... [Pg.108]

Pabreza LA, Dhawan S, KeUar KJ (1991) [ H]cytisine binding to nicotinic cholinergic receptors in brain. Mol Pharmacol 39 9-12... [Pg.109]

Pauly JR, Collins AC (1993) An autoradiographic analysis of alterations in nicotinic cholinergic receptors following 1 week of corticosterone supplementation. Neuroendocrinology 57 262-271... [Pg.110]

Schwartz RD, McGee R Jr, Kellar KJ (1982) Nicotinic cholinergic receptors labeled by [ H]acetylchohne in rat brain. Mol Pharmacol 22 56-62... [Pg.111]

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