Nicholls studies

Nicholls and Svenson [14] have also studied the thermal treatment of MIPs in order to assess the thermal stability of the common MAA/EGDMA matrix of MIPs. The results were consistent with those reported by Sellergren et al. as thermal annealing above I50°C led to a loss in affinity for the template, theophylline. Nicholls study suggests a further explanation for the loss of selectivity upon thermal treatment. The drop in affinity and selectivity was correlated to the decarboxylation of... 

H. W. Spencer, 111, and G. B. Nichols, "A Study of Rappiug Re-entrainment ia a Large Pilot Electrostatic Precipitator," Preprint 76-42.5, 68th MPCA. MnnualMeeting Portland, Oregon, June 27—July 1, 1976. 

Nichols Chart for Case Study Example 6.6 %Lead Compensator Design One, Figure 6.34 clf... 

Nichols DE Studies ofthe relationship between molecular structure and hallucinogenic activity. Pharmacol Biochem Behav 24 335-340, 1986 Nichols DE Hallucinogens. Pharmacol Ther 101 131-191, 2004 Peroutka SJ Serotonin receptors, in Psychopharmacology The Third Generation of Progress. Edited by Meltzer HY. New York, Raven, 1987, pp 303-311 Perry PJ, Wilding OC, Juhl RP Anticholinergic psychosis. Am J Hosp Pharm 35 725— 728, 1978... 

McCombs JS, Nichol MB, Stimmel GL, et al (1990). The cost of antidepressant drug therapy failure a study of antidepressant use patterns in a Medicaid population. J Clin Psychiatry (6, suppL), 60—9. 

The first IR studies detected the formation and adsorption of CO, and therefore CO was proposed as the poisoning intermediate [Beden et al., 1981 Nichols and Bewick, 1988 Corrigan and Weaver, 1988]. The formation of CO is stmcture-dependent and takes place at open circuit, and the maximum amount accumulated on the electrode... 

In view of the apparent pleasurable effects of MDMA, it becomes of considerable interest to understand the mechanism of action of substances with a similar effect. Major efforts have been directed toward the study of agents that have an effect on serotonin pathways, since that is the neurotransmitter system that seems most implicated in the mechanism of action of MDMA. This hypothesis is further reinforced by the observation that MDMA substitutes for fenfluramine (Schechter 1986). and fenfluramine substitutes for MBDB (Oberlender and Nichols, unpublished). The substitution data for (+)-amphetamine and cocaine in (-t-)-MBDB-trained rats are also similar to the data for substitution of these agents in fenfluramine-trained rats (White and Appel 1981). 

A variety of side-chain modified analogs of MDMA and MBDB have begun to be examined. Very early studies were of the a,a-dimethyl analog, 3,4-methylenedioxyphentermine (figure 8a) and its N-methyl derivative (figure 10). This latter compound proved to lack MDMA-like activity (Shulgin, unpublished). Interestingly, this compound also lacked the ability to stimulate the release of [ H] serotonin from prelabeled rat brain synaptosomes (Nichols et al. 1982). 

Oberlender, R., and Nichols, D.E. Drug discrimination studies with MDMA and amphetamine. Psychopharmacology (Berlin) 95 71-76, 1988. 

Cheng, H.C. Long, J.P. Nichols, D.E. and Barfknecht, C.F. Effects of psychotomimetics on vascular strips Studies of methoxylated amphetamines and optical isomers of 2,5-dimethoxy4-methylamphetamine and 2.5-dimethoxy-4-bromoamphetamine. J Pharmacol Exp Ther 188 114-123, 1974. 

In 1970, Charlton and Nichols [340] published their results of a Au Mossbauer study on 31 gold complexes, for which they describe a general correlation between Mossbauer parameters and chemical features. They investigated the series... 

Shelley W., Hurley H. and Nichols A. (1953). Axillary odor, an experimental study of the role of bacteria, apocrine sweat, and deodorants. Arch Dermatol 68, 430-446. 

Costello, C. P., C. O. Bock, and C. C. Nichols, 1965, A Study of Induced Convective Effects on Pool Boiling Burnout, AIChE Chem. Eng. Prog. Symp. Ser. 6/ 271-280, (2)... 

Bartlett JG, Condon RE, Gorbach SL, Clarke JS, Nichols RL, Ochi S Veterans Administration Cooperative Study on Bowel Preparation for Elective Colorectal Operations Impact of oral antibiotic regimen on colonic flora, wound irrigation cultures and bacteriology of septic complications. Ann Surg 1978,188 249-254. 

Clarke JS, Condon RE, Bartlett JG, Gorbach SL, Nichols RL, Ochi S Preoperative oral antibiotics reduce septic complications of colon operations Results of a prospective, randomized, double-blind clinical study. Ann Surg 1977 186 251-259. 

This section is a selective review of behavioral pharmacology studies in animals and humans that are consistent with a postsynaptic serotonergic action of LSD-like hallucinogens. (See also the chapters by Davis et al., Appel and Rosecrans, and Nichols and Glennon, this volume.)... 

Cheng, H. C., Long, J. P., Nichols, D. E., Barfknecht, C. F., and Rusterholz, D. B. (1974) Effects of rigid amphetamine analogs on vascular strips Studies of 2-aminotetrahydronaphthalene and 2-aminoindane derivatives. Arch. Int. Pharmacodyn. Ther., 208 264-273. 

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