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Niacin, extended-release

Several different niacin formulations are available niacin immediate-release (IR), niacin sustained-release (SR), and niacin extended-release (ER).28,29 These formulations differ in terms of dissolution and absorption rates, metabolism, efficacy, and side effects. Limitations of niacin IR and SR are flushing and hepatotoxicity, respectively. These differences appear related to the dissolution and absorption rates of niacin formulations and its subsequent metabolism. Niacin IR is available by prescription (Niacor ) as well as a dietary supplement which is not regulated by the FDA.28 Currently, there are no FDA-approved niacin SR products, thus, all SR products are available only as dietary supplements. [Pg.189]

The usual recommended starting dose for extended-release niacin tablets is 500 mg at bedtime. Niacin extended-release tablets must be titrated and the dose should not be increased by more than 500 mg every 4 weeks up to a maximum dose of 2000 mg/day, to reduce the incidence and severity of side effects. Patients already receiving a stable dose of niacin extended-release tablets may be switched directly to a niacin-eguivalent dose of niacin extended-release/lovastatin tablets. [Pg.637]

Take niacin extended-release/lovastatin tablets at bedtime, with a low-fat snack, and individualize dose according to patient response. [Pg.637]

Take whole do not break, chew, or crush before swallowing. Do not increase the dose by more than 500 mg/day (based on the niacin extended release component) every 4 weeks. The lowest dose of niacin extended-release/lovastatin tablets is 500/20 mg. Doses greater than 2000/40 mg/day are not recommended. If therapy is discontinued for an extended period (greater than 7 days), begin reinstitution of therapy with the lowest dose. [Pg.637]

ADVICOR (Kos) (niacin extended-release/lovastatin tablets) November 2003 labeling... [Pg.261]

Moon YS, Kashyap ML. Niacin extended-release/Lovastatin combination therapy for hpid disorders. Expert Opin Pharmacother 2002 3 1763-71. [Pg.1156]

Insull Jr. W, Basile JN, Vo AN, Jiang P, Thakkar R, Padley RJ. Efficacy and safety of combination therapy with niacin extended-release and simvastatin versus atorvastatin in patients with dyslipidemia The SUPREME Study. J Clin Lipidol 2009 3(2) 109-18. [Pg.934]

Niaspan) Extended-release niacin + tablets N iaci n/lovastatin 500mg/20 500 mjy20 mg 1,000 mg/... [Pg.118]

Gl Abdominal pain, activation of peptic ulcer, diarrhea, dyspepsia, nausea, vomiting. The frequency of Gl complaints is higher in users of extended-release niacin. Gl distress can be minimized by dividing the total daily dose into a twice daily or 3 times daily dosage regimen. [Pg.9]

Extended-release niacin Simitar to regular niacin ... [Pg.793]

Sustained-release niacin (not the same as extended-release product) Should be avoided ... [Pg.793]

Oral 10, 20, 40 mg tablets extended release (Altoprev) 10, 20, 40, 60 mg Niacin, nicotinic acid, vitamin B3 (generic, others)... [Pg.794]

Simcor (extended release niacin plus simvastatin)... [Pg.794]

Goldberg AC. Clinical trial experience with extended-release niacin (Niaspan) dose-escalation study. Am J Cardiol 1998 82 35U-38U. [Pg.565]

Guyton JR, Goldberg AC, Kreisberg RA, Sprecher DL, Superko HR, O Connor CM. Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia. Am J Cardiol 1998 82 737M3. [Pg.565]

Goldberg A, Alagona DP Jr, Capuzzi DM, Guyton J, Morgan JM, Rodgers J, Sachson R, Samuel P. Multiple-dose efficacy and safety of an extended-release form of niacin in the management of hyperlipidemia. Am J Cardiol 2000 85 1100-5. [Pg.565]

Other bothersome side effects are related to specific agents. Niacin, for instance, is often associated with cutaneous vasodilation and a sensation of warmth when doses are administered, but administering an extended-release form of this drug can reduce these sensations.71 99 Some fairly serious problems, including liver dysfunction, gallstones, and pancreatitis, can occur with many antihyperlipidemia drugs, but the incidence of these side effects is rare. Cardiovascular problems such as arrhythmias, blood dyscrasias, and angioneurotic syndrome may also occur with fibric acids. [Pg.360]

Guyton JR. Extended-release niacin for modifying the lipoprotein profile. Expert Opin Pharmacother. 2004 5 1385-1398. [Pg.364]

Niacin and acipimox should be relatively safe to use in the absence of varices, gastritis, coagulopathy, thrombocytopenia or a history of decompensation. Both can cause pruritus, which is common in cholestatic liver disease. The extended release formulation of niacin (Niaspan Prolonged Release) may cause hepatitis and LFTs should be monitored. [Pg.228]

Niacin is readily absorbed from the gastrointestinal tract. The peak serum concentration for an immediate release oral dosage form is usually seen within 45 min of niacin ingestion 4-5 h for an extended release tablet. Niacin is hepatically metabolized and widely distributed into body tissues. Niacin is renally excreted. Excess amounts of niacin, beyond daily needs, are excreted largely unchanged in the urine. The plasma half-life is 45 min. [Pg.1803]

Some combinations of lipid-altering drugs are currently available such as extended-release niacin/lovastatin and ezetimibe/simvastatin, which are more promising for lipid-lowering therapy with stronger effects and decreased adverse reactions. [Pg.114]

Niacin TLDL and VLDL Synthesis 4-Triglyceride and cholesterol 4VLDL, 4LDL, fHDL Problems with patient acceptance good in combination with bile acid resins extended-release niacin causes less flushing and is less hepatotoxic than sustained-release niacin... [Pg.440]

Extended-release niacin + Kos Niacin/lovastatin 500-mg/20-mg Niacin/lovastatin Niacin/lovastatin... [Pg.441]

See other pages where Niacin, extended-release is mentioned: [Pg.636]    [Pg.1119]    [Pg.636]    [Pg.1119]    [Pg.74]    [Pg.88]    [Pg.118]    [Pg.140]    [Pg.182]    [Pg.187]    [Pg.632]    [Pg.788]    [Pg.564]    [Pg.681]    [Pg.243]    [Pg.105]    [Pg.78]    [Pg.2516]    [Pg.1116]    [Pg.289]    [Pg.441]   
See also in sourсe #XX -- [ Pg.179 , Pg.182 ]



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