Neuronal signaling proteins

The cdr2 antigen, the target antigen of the Yo antibodies in paraneoplastic cerebellar degeneration, is located in the cytoplasma. The cdr2 protein is a neuronal signaling protein, and is, like the Ma proteins, normally expressed... 

RamaRao, G., Bhattacharya, B.K., Kumar, S., et al., 2011. Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication. Toxicol 293, 195-202. 

Fivaz, M. and Meyer, T. Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions. Neuron 40 319-330, 2003. 

The Ca Vcalmoduhn complex is a signal molecule that is involved in many signal transduction pathways. Ca Vcalmoduhn is involved in regulation of proliferation, mitosis, and in neuronal signal transduction. Different calmodulin subtypes are known which regulate different target proteins. 

The best characterized substrate of Ca Vcalmodulin is the Ca /calmodulin-depen-dent protein kinase (CaM kinase). CaM kinase has an important function in neuronal signal transduction. The mechanism of Ca Vcalmodulin activation of CaM kinase is described in more detail in Section 7.4, together with regulation of protein kinases. Another substrate of Ca Vcalmodulin is myosin light chain kinase (MLCK), involved in contraction of smooth musculature. 

Calakos N, Schoch S, Siidhof TC et al (2004) Multiple roles for the active zone protein RIMlalpha in late stages of neurotransmitter release. Neuron 42 889-96 Calvert PD, Strissel KJ, Schiesser WE et al (2006) Light-driven translocation of signaling proteins in vertebrate photoreceptors. Trends Cell Biol 16 560-8 Capogna M, Gahwiler BH, Thompson SM (1996) Presynaptic inhibition of calcium-dependent and -independent release elicited with ionomycin, gadolinium, and alpha-latrotoxin in the hippocampus. J Neurophysiol 75 2017-28... 

ORNs are a large population of similar but distinct neurons. The genetic differentiation of such a group is an interesting functional and developmental problem. OR expression clearly is important but it is likely that other proteins are differentially expressed as well. A complex of signaling proteins and transcription factors determines the functional identity of the components of the olfactory network during development. The functional properties of this network during active life are then defined by the interaction of receptors, neurotransmitters... 

Musunuru K, Darnell RB. Paraneoplastic neurologic disease antigens RNA-binding proteins and signaling proteins in neuronal degeneration. Annu Rev Neurosci 2001 24 239-262. 

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