Neurological damage

Zivin JA, Fisher M, DeGirolami U, Hemenway CC, Stashak JA. Tissue plasminogen activator reduces neurological damage after cerebral embolism. Science. 1985 230 1289-1292. 

Zivin JA, Lyden PD, DeGirolami U, Kochhar A, Mazzarella V, Hemenway CC, Johnston P. Tissue plasminogen activator. Reduction of neurologic damage after experimental embolic stroke. Arch Neurol. 1988 45 387-391. 

An anti-intracellular adhesion molecule-1 (anti-ICAM-1) antibody reduced neurological damage in a rabbit embolic model of stroke followed by thrombolysis with tissue-type plasminogen activator (tPA). When thrombolysis was delayed for 3 h following embolism, neither tPA nor the tPA/ICAM combination reduced neurological damage. 

Disease-modifying therapies are used to decrease the number of relapses, prevent permanent neurologic damage, and prevent disability. 

The overall goal of MS treatment is to prevent permanent neurologic damage. There are three general approaches to... 

Treatment of SCD is aimed at the preventing and/or minimizing acute and chronic complications, including infection, acute chest syndrome, neurologic damage, and the various forms of sickle cell crises, including vaso-occlusive pain, splenic sequestration, and aplastic crisis. The acute and chronic complications are summarized in Tables 65-2,65-3, and 65-4. 

Polyalphaolefin Hydraulic Fluids. There is limited information on the potential of polyalphaolefin hydraulic fluids to induce musculoskeletal effects. Kyphosis, a deformity of the spine characterized by extension flexion was observed in rats exposed to 880-5,030 mg/m3 (concentration eliciting response not reported) of a polyalphaolefin hydraulic fluid designated at B85-174 for 4 hours (Kinkead et al. 1987b). It is not known if this effect is related to damage to the musculoskeletal system or to neurological damage. This is the only study that examined musculoskeletal effects. Thus, the likelihood of musculoskeletal effects occurring in humans exposed to polyalphaolefin hydraulic fluids cannot be determined. 

Padilla S, Veronesi B. 1985. The relationship between neurological damage and neurotoxic esterase inhibition in rats acutely exposed to tri-ortho-cresyl phosphate. Toxicol Appl Pharmacol 78 78-87. 

Hazard Identification. Does a chemical substance or mixture cause adverse human health effects, such as cancer, birth defects, neurological damage, etc While It would be useful to have an unequivocal positive or negative answer to this question, that Is rarely possible. The usual situation Is that similarity to... 

GB interferes with neural synapses. It causes overstimulation of the nervous system, which in turn causes over-reactivity in the muscles and malfunctioning of various body organs. Exposure to GB will result in massive congestion of enzymes and fluids in all the major organs, throughout the nervous system, and within the brain. Those who survive exposure may suffer permanent neurological damage.1... 

An epidemic of intoxication from ingestion of fish contaminated with methyl mercury occurred in the Minamata district in Japan, and, as a result, methyl mercury intoxication is often referred to as Minamata disease." Infants born to mothers with exposure to large amounts of methyl mercury had microen-cephaly, mental retardation, and cerebral palsy with convulsions. In an incidence in Iraq, ingestion of wheat products contaminated with methyl mercury fungicide by pregnant women caused similar symptoms of neurological damage and mental retardation. The fetus is... 

Hyponatremia/Hypochloremia - A chloride deficit is generally mild and usually does not require specific treatment, except in extraordinary circumstances (as in liver or renal disease). Thiazide-induced hyponatremia has been associated with death and neurologic damage in elderly patients. 

Maternal PKU occurs when a pregnant woman with uncontrolled PKU has high levels of Phe in her blood, leading to elevated levels of Phe in fetal blood and consequent neurologic damage, including microcephaly and mental retardation. 

Pregnant women with PKU should maintain a low-Phe diet to avoid inducing neurologic damage and potential mental retardation in the fetus, since fetal phenylalanine hydroxylase activity acquired from the father would be inadequate to metabolize the mother s high plasma Phe. 

Without a firm diagnosis folic acid should not be given to all patients with megaloblastic anemia as irreversible neurological damage from vitamin B12... 

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