Neuroimmune interactions

Javed, N.H., Wang, Y.Z. and Cooke, H.J. (1992) Neuroimmune interactions role for cholinergic neurons in intestinal anaphylaxis. American Journal of Physiology 263, G847-G852. 

Nockher WA, Renz H. 2006. Neurotrophins and asthma Novel insight into neuroimmune interaction. J All Clin Immunol. 117 67-71. 

The above discussion of BBB fundamentals is tailored towards understanding the role of the BBB in neuroimmune interactions. Below are specific examples of how the BBB is involved in neuroimmune interactions. 

The above review has emphasized BBB/neuroimmune interactions under normal physiological conditions. However, the BBB is intimately involved in neuroimmune diseases as well. The BBB can be a target of such disease, its functions may be adaptive to disease, or it can be a contributor to the disease process. Below are some examples of the ways in which the BBB is altered in diseases with neuroimmune processes. 

The studies reviewed in this chapter demonstrate that a strong and reciprocal relationship exists between the central nervous system and the immune system. Indeed, the term neuroim-mune system is clearly justified and appropriate to emphasize the fact that nervous and lymphoid tissues constitute a unified system that functions in the maintenance of homeostasis. The conventional division between the two systems has blurred, as well as the distinction between neuropeptides on the one hand, and immune cytokines on the other. Two lines of research have altered our perspective on neuroimmune interactions (a) the identification of conventional neuropeptides and then-receptors, especially those related to the HPA axis, in most lymphoid tissues, and (b) the large body of evidence that cytokines, historically associated with immune system communication, play vital roles in nervous function. 

Other novel pathways for therapeuhc intervenhon have focused on neuroimmune interactions and the use... 

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