Neurogenic effects

To study the functional implication of such observations, Santarelli et al. (2003) aimed at determining if an increase in neurogenesis is required for the effect of antidepressants. X-ray irradiation of the hippocampal area in adult rats causes long-term reduction in cell proliferation in the DG (Tada et al., 2000). Hippocampal x-ray irradiation, but not irradiation of other brain areas - like the SVZ or the cerebellar region - prevented the neurogenic effect... 

Suzuki, M., Wright, L. S., Marwah, P., Lardy, H. A. and Svendsen, C. N. Mitotic and neurogenic effects of dehydroepiandrosterone (DHEA) on human neural stem cell cultures derived from the fetal cortex. Proc Natl Acad Sci USA 101 (2004) 3202-3207. 

Khawaja, A.M., Liu, Y.C., and Rogers, D.F., Effect of fenspiride, a non-steroidal anti-inflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro, Pulm. Pharmacol. Then, 12, 363-368, 1999. 

No neoplastic effect was observed in rats exposed to 0, 15, 45, or 135ppm for 6 hours/ day, 5 days/week for 2 years. Dose-related changes, which include atrophy of the neurogenic epithelial cells and hyperplasia of the reserve cells, mainly affected the anterior part of the olfactory epithelium. In the high-dose group there was opacity of the cornea. After a 6-month postexposure period reconstructive effects were observed in both tissues. 

Matsumoto, K., Yamamoto, L. T., Watanabe, K., Yano, S., Shan, J., Pang, J., Pang, P. K., Ponglux, D., Takayama, H. and Horie, S. 2005. Inhibitory effect of mitragynine, an analgestic alkaloid from Thai herbal medicine, on neurogenic contraction of the vas deferens. Life Sciences, 78 187-194. 

Papaverine is highly effective in men with psychogenic and neurogenic ED but less effective in men with vasculogenic ED. Papaverine-phentolamine combinations have been used in self-injection procedures. Papaverine doses may range from 15 to 60 mg. Papa-... 

Other Uses in Geriatric Patient Partial neurogenic diabetes insipidus Side Effects ... 

Noradrenaline is used to treat shock-like conditions associated with peripheral vasodilatation, e.g. sepsis, systemic inflammatory response syndrome (SIRS), neurogenic shock. The rationale of its use in sepsis and SIRS is to counteract the vasodilatory effects of nitric oxide. Following the surgical removal of phaeochromocytoma and similar tumours, noradrenaline is often given to maintain blood pressure in the initial period. During and after cardiac surgery, it may be used to optimise haemodynamic parameters in combination with other drugs, such as phosphodi-esterase inhibitors. Dose... 

Bethanechol Muscarinic agonist t negligible effect at nicotinic receptors Activates Mi through M3 receptors in all peripheral tissues causes increased secretion, smooth muscle contraction (except vascular smooth muscle relaxes), and changes in heart rate Postoperative and neurogenic ileus and urinary retention Oral and parenteral, duration 30 min does not enter central nervous system (CNS) Toxicity Excessive parasympathomimetic effects, especially bronchospasm in asthmatics Interactions Additive with other parasympathomimetics... 

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