Neurofibrillary tangles, aluminum associate with

Neurofibrillary tangles, aluminum associate with, 36 416-417 Neuromodulin, 46 449 Neuromuscular blocking agents, 36 7 Neuron-specific calcium sensor (NCS) proteins, 46 457... 

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Increased brain aluminum accumulation is known to be associated with neurofibrillary tangles in some species. The terms neurofibrillary tangle or "neurofibrillary degeneration refer to an accumulation of tangles of neurofibers within the neuron. Electron microscopic examination of aluminum-induced neurofibrillary tangles indicates that they consist of areas of cytoplasmic clearings, filled with either compact orderly bundles or accumu-... 

Aside from the amyloid based model for AD, iron was also demonstrated to enhance phosphorylation of Tau and the formation of the neurofibrillary tangles associated with the AD brain [10]. In this report a novel trivalent cationic chelator, Feralex, effectively dissociated binding of aluminum and iron to hyperphosphorylated Tau (neurofibrillary tangle) pertinent to its use as a therapeutic agent for AD. 

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