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Free radical neurodegenerative disorders

The excessive activity of excitatory amino acids, such as L-glutamate and L-aspartate, followed by elevation of intracellular free Ca2+ concentration and accumulation of free radicals has been postulated to underlie the neurodegeneration that occurs after ischemic insults and trauma. Additionally, an excitotoxic component has been shown to play an important role in the pathogenesis of chronic neurodegenerative disorders, such as Alzheimer s disease, Parkinson s disease, amyotrophic lateral sclerosis, and Huntington s disease, which are characterized by progressive loss of neuronal elements. [Pg.173]

Mattson, M.P., Cheng, B. and Smithswintosky, V.L. (1993b) Mechanisms of neurotrophic factor protection against cal-cium-and free radical-mediated excitotoxic injury - implications for treating neurodegenerative disorders. Exp. Neurol. 124 89-95. [Pg.369]

See other pages where Free radical neurodegenerative disorders is mentioned: [Pg.826]    [Pg.243]    [Pg.352]    [Pg.355]    [Pg.156]    [Pg.428]    [Pg.174]    [Pg.368]    [Pg.525]    [Pg.144]    [Pg.274]    [Pg.28]    [Pg.826]    [Pg.368]    [Pg.582]    [Pg.595]    [Pg.641]    [Pg.163]    [Pg.641]    [Pg.440]    [Pg.128]    [Pg.204]    [Pg.516]    [Pg.105]    [Pg.662]    [Pg.394]    [Pg.20]    [Pg.292]    [Pg.380]    [Pg.373]    [Pg.242]    [Pg.35]    [Pg.324]    [Pg.1480]    [Pg.1968]    [Pg.2593]    [Pg.3543]    [Pg.4708]    [Pg.305]    [Pg.450]    [Pg.91]    [Pg.22]    [Pg.148]   
See also in sourсe #XX -- [ Pg.36 , Pg.37 , Pg.38 , Pg.39 ]



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Neurodegenerative disorders

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