Future Directions in Neurogenesis for Neurodegenerative Disorders

Endogenous Adult Stem Cells as a Therapeutic Strategy 

Recent evidence confirms the widespread occurrence of neural stem cells and the production of new neurons in many parts of adult brain. Although the regeneration of new neurons has been observed only at a very low frequency and can only replace a small fraction of neurons (Fallon etal, 2000 Magavi etal., 2000), these findings encourage work toward 

Finally, much of the biology of regeneradon of nervous system dssue has yet to be discovered. Many of the factors that contribute to regeneradon and/or that prevent it remain unknown. NSCs may provide as yet unidendfied factors to host dssue, enabling or enhancing regeneradon of damaged dssue. 

Shelley Herek, David Erichsen, Alicia Lopez, Ziyuan Duan, Nathan Erdmann, Dongsheng Xu, Li Wu, Clancy McNalley, and Jianxing Zhao provided technical support for this work. Julie Ditter, Robin Taylor, Myhanh Che, Nell Ingraham, and Emile Scoggins provided outstanding adminishative support. 

Wliich cell type is not likely deiived from neural stem/ progenitor cells  

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