Neurodegenerative disease oxidative injury

Greco A, Minghetti L, Levi G. 2000. Isoprostanes, novel markers of oxidative injury, help understanding the pathogenesis of neurodegenerative diseases. Neurochem Res 25 1357-1364. 

Our emphasis on the interplay among excitotoxicity, oxidative stress, and neuroinflammation does not rule out the participation of other mechanisms involved in neural cell injury. However, it is timely and appropriate to apply the concept of interplay among excitotoxicity, oxidative stress, and neuroinflammation to neural cell injury in acute neural trauma and neurodegenerative diseases. Lack of coordination among the above parameters may control the time taken by neural cells to... 

Oxidative stress e Injury e Ischemia e Seizures e Neurodegenerative diseases... 

Unbalanced production of reactive oxygen species, first of aU superoxide and hydrogen peroxide, has been postulated as playing a role in the pathogenesis of a number of chnical disorders, such as acute respiratory distress syndrome, ischemia-reperfusion injury, atherosclerosis, neurodegenerative diseases and cancer. As the function of SOD and CAT is the protection against oxidative stress, their apphcation has been proposed in cases where oxidative stress is important in the mechanism of a disease. 

Oxidative stress, rather than being the primary cause of disease, is more often a secondary complication in many disorders. Oxidative stress diseases include inflammatoiy bowel diseases, retinal ischemia, cardiovascular disease and restenosis, AIDS, ARDS, and neurodegenerative diseases such as stroke. Parkin-son s disease, and Alzheimer s disease. Such indications may prove amenable to antioxidant treatment because there is a clear involvement of oxidative injury in these disorders. 

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