Acute neural trauma

Table 8.3 Status of neuroinflammation, oxidative stress, and NF-/cB in acute neural trauma and neurodegenerative diseases...

Our emphasis on the interplay among excitotoxicity, oxidative stress, and neuroinflammation does not rule out the participation of other mechanisms involved in neural cell injury. However, it is timely and appropriate to apply the concept of interplay among excitotoxicity, oxidative stress, and neuroinflammation to neural cell injury in acute neural trauma and neurodegenerative diseases. Lack of coordination among the above parameters may control the time taken by neural cells to... 

ROS play a critical role in initiation of apoptosis through changes in mitochondrial permeability, andpoly(ADP-ribose) polymerase (PARP) activation. These processes provide additional mechanisms for oxidative damage in acute neural trauma and neurodegenerative diseases (Warner et al., 2004). PARP activation is accompanied by the depletion of nicotinamide adenine dinucleotide, NAD. Depletion of NAD leads to depletion of ATP, which in turn promotes neuronal cell death (Zhang etal., 1994 Ishikawaetal., 1999). 

Table 1.1 Neurochemical events that are common to acute neural trauma, neurodegenerative diseases, and neuropsychiatric disorders...

Parameter Acute neural trauma Neurodegenerative diseases Neuropsychiatric diseases... 

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