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Neuritogenic activity

The Japanese sea cucumber Cucumaria echinata contained a ganglioside CG-1 (664) with neuritogenic activity toward the rat pheochromocytoma PC-12 cell line [526]. Similar activity was reported for the ganglioside HPG-8 (665) isolated from the sea cucumber Holothuria pervicax from Japan [527]. [Pg.720]

Linckosides A (38) and B (39) differ in the sugar unit attached to C-29, an a-arabinofuranosyl in 38 and a xylose unit in 39. Linckosides C (40) and D (41) are the first steroids that possess a hydroxyisopropyl substituent at C-24 of the side chain. The neuritogenic activity of diglycosides 38-42 was evaluated using rat pheochromocytoma (PC 12) cells in comparison with NGF (nerve growth factor). Linckosides B, C and D with a xylose unit in the side chain showed significant neuritogenic activities of 62%, 56% and 73%, respectively, comparable with that of NGF. [Pg.325]

On the other hand, linckosides A and B with an arabinose unit at the side chain exhibited lower activities (33% and 29%, respectively) than the others. This result suggests that the nature of the sugar moiety at the side chain plays an important role for the neuritogenic activity and that other structural factors, such as the presence or absence of a methyl group at C-28 and the double bond at C-22, seemed not to be important. All the linckosides showed significant synergistic effects on the NGF-induced neuronal differentiation of PC 12 cells. [Pg.325]

Evaluation of the neuritogenic activity of five new monoglycosides isolated from the starfish Linckia laevigata demonstrated that the nature of the sugar moiety attached to the side chain seems to be an important factor for the neuritogenic activity. [Pg.348]

C.D. Nandini, N. Itoh, K. Sugahara, Novel 70-kDa chondroitin sul-fate/dermatan sulfate hybrid chains with a unique heterogeneous sulfation pattern from shark skin, which exhibit neuritogenic activity and binding activities for growth factors and neurotrophic factors, J. Biol. Chem. 280 (6) (2005) 4058-4069. [Pg.86]

Arao, K., Inagaki, M., Miyamoto, T, and Higuchi, R. (2004) Constituents of crinoidea. 3. Isolation and structure of a glycosyl inositolphosphoceramide-type ganglioside with neuritogenic activity from the feather star Comanthus japonica. Chem. Pharm. Bull., 52, 1140-1142. [Pg.789]

Bao, X., Mikami, T., Yamada, S., Faissner, A., Mmamatsu, T., and Sugahara, K. (2005) Heparin-binding growth fador, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains. J. Biol. Chem., 280, 9180-9191. [Pg.902]

Fuchuan, L., Kumar Shetty, A., and Sugahara, K. (2007) Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and iheir mimicry from shark liven involvement of the pleiotrophin and hepatocyte growth factor signaling pathways./. Biol. Chem.. 282, 2956-2966. [Pg.903]


See other pages where Neuritogenic activity is mentioned: [Pg.151]    [Pg.140]    [Pg.25]    [Pg.1453]    [Pg.223]    [Pg.224]    [Pg.225]    [Pg.713]    [Pg.796]    [Pg.1277]   
See also in sourсe #XX -- [ Pg.28 , Pg.720 ]




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Cucumaria echinata neuritogenic activity

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