Neural lesions

Wiley, R.G. (2000). Molecular neurosurgery using plant toxins to make highly selective neural lesions, in Tu, A.T. and Gaffield, W., Eds., Natural and selected synthetic toxins Biological implications, American Chemical Society, Washington, pp. 194-203. 

Luo, Y., Bolon, B., Damore, M.A., Fitzpatrick, D., Liu, H., Zhang, 1,Yan, Q., Vassar, R., Citron, M. BACE1 ((3-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiol. Dis. 2003, 14, 81-88. 

McDonough, J.H., Clark, T.R., Slone, T.W., Jr., Zoeffel, D., Brown, K., Kim, S., Smith, C.D. (1998). Neural lesions in the rat and their relationship to EEG delta activity following seizures induced hy the nerve agent soman. Neurotoxicology 19 381-92. 

Lung biopsies performed in a small number of patients revealed a vasculitis and perivasculitis with a chronic interstitial pneumonitis. Disturbances of cardiac rhythm and conduction have also been documented. Examination of cardiac autopsy specimens has demonstrated neural lesions throughout the conduction system, similar to the neuropathology seen in skeletal muscle. Inflammatory lesions of the small coronary arteries were also present. The prevalence of cardiac abnormalities among all patients with EMS is unknown, although life-threatening rhythm disturbances appear to be uncommon. 

In conclusion, the following summarizes possible correlative biological markers of early carbon disulfide poisoning (1) electromyographical indications of neural lesions (2) decreased neuromuscular conduction... 

Geyer, M. A., Petersen, L. R., and Rose, G. J. (1980) Effects of serotonergic lesions on investigatory responding by rats in a holeboard. Behav. Neural Biol., 30 160-177. 

Neurotoxicity can be defined as any adverse effect on the structure or function of the nervous system related to exposure to a chemical substance (US-EPA 1998, OECD 2004c). According to the TGD (EC 2003), neurotoxicity can be defined as the induction by a chemical of adverse effects in the central or peripheral nervous system, or in sense organs and a substance is neurotoxic if it induces a reproducible lesion in the nervous system or a reproducible pattern of neural dysfunction. ... 

Occasionally the nervous system becomes involved in myelomatosis, and a number of cases have been reported. The lesions in these patients include compression of neural structures by myeloma tissue or collapsed vertebra, herpes zoster, and amyloid infiltration of the peripheral nervous system. Although uncommon, a peripheral neuromyopathy in which there is no direct involvement of nerves or nerve roots has been reported, but the association of multiple myeloma with neuropathy and osteosclerotic lesion is rarer and even more unusual. Osuntokun et al. (05) has reported such a patient in Africa whose outstanding clinical features were widespread neuromyopathy associated with multiple myeloma, and general-... 

Stephan FK 2002 The other circadian system. Food as a Zeitgeber. J Biol Rhythms 17 284-292 Stephan FK, Swann JM, Sisk CL 1979 Anticipation of 24-hr feeding schedules in rats with lesions of the suprachiasmatic nucleus. Behav Neural Biol 25 346—363 Stephan FK, Zucker I 1972 Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci USA 69 1583-1586 Stokkan KA, Yamazaki S, Tei H, Sakaki Y, Menaker M 2001 Entrainment of the circadian clock in the liver by feeding. Science 291 490-493... 

Hastings The pathways that are necessary for masking to occur will run through the chiasm, even if they are not synapsing in the SCN. If you lesion other afferents to the midbrain or thalamus you may take away the neural substrate for masking with a large or misplaced SCN lesion. 

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