Network orchestration

Thiery, J.P. and Sleeman, J.P. (2006) Complex networks orchestrate epithelial—mesenchymal transitions. Nature Reviews. Molecular Cell Biology,... 

Value networks do not just happen. Extending the supply chain outward from the enterprise through strategic relationships is an integral piece of the supply chain strategy. It takes time. It is a staged progression. Concentrated effort and a shared vision are essential. Network orchestration is critical. 

Staff and plan for risk scenarios. As the network is outsourced, the need for network orchestration increases. Since the building of networks is often a focused effort to reduce costs, companies new at building networks usually understaff coordination. As a result, the supply chain becomes more fragile. 

Build capabilities for network orchestration. While you can outsource value chains, you cannot outsource the risk of the value chain. As the supply chain is outsourced, staff for value chain orchestration and process coordination. 

Thiery, J.R, and Sleeman, J.R (2006). Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7, 131-142. 

Keaveney M, Struhl K Activator-mediated recruitment of the RNA polymerase machinery is the predominant mechanism for transcriptional activation in yeast. Mol Cell 1998 1 917. Lemon B, Tjian R Orchestrated response a symphony of transcription factors for gene control. Genes Dev 2000 l4 255l. Maniatis T, Reed R An extensive network of coupling among gene expression machines. Nature 2002 416 499. 

Network formation and crosstalk endows the cell with a great plasticity and variability in signal transmission. Each cell receives at a time a large number of signals and the responses on these signals must be fine tuned and orchestrated in a way that is optimal for the growth and development of the organism. 

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