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Nerve agents gastrointestinal effects

The human intravenous bolus dose of oximes in nerve agent treatment ranges between 250 and 500 mg ". Side effects of oxime treatment in humans were monitored in 750 volunteers, and the main adverse effects reported were changes in blood pressure, pulse rate, dizziness, nausea and blurred vision . Oral administration of oximes produces gastrointestinal distress. ... [Pg.644]

Toxic effects occur within seconds to 5 min of nerve agent vapor or aerosol inhalation. The muscarinic effects include ocular (miosis, conjunctival congestion, ciliary spasm), nasal discharge, respiratory (bronchoconstriction and increased bronchial secretion), gastrointestinal (anorexia, vomiting, abdominal cramps, and diarrhea), sweating, salivation, and cardiovascular (bradycardia and hypotension) effects. The nicotinic effects include muscular fa-sciculation and paralysis. CNS effects can include ataxia, confusion, loss of reflexes, slurred speech, coma, and paralysis. [Pg.2351]

V. Gastrointestinal Effects of Nerve Agent Aerosol Exposure.239... [Pg.233]

V. GASTROINTESTINAL EFFECTS OF NERVE AGENT AEROSOL EXPOSURE... [Pg.239]

Lead. Toxic metal to which there is wide exposure. Exposure is via inhalation (main source leaded petrol) and ingestion (water, old paint). Multi-organ toxicity occurs with kidneys, central and peripheral nervous system, testes, red cells, bones and gastrointestinal tract all damaged. After initial distribution into red blood cells it is eventually deposited in bone. The main biochemical effect is interference with haem synthesis at several points. Kidney toxicity may be due to lead-protein complexes and inhibition of mitochondrial function. Damage to nerves leads to peripheral neuropathy. Treatment involves use of chelating agents (EDTA). [Pg.667]


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See also in sourсe #XX -- [ Pg.145 , Pg.168 ]




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Nerve agents effects

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