Nephrotoxicity mechanism

Porter, G.A., Ed., Nephrotoxic Mechanisms of Drugs and Environmental Toxins, Plenum Medical Book Co., New York, 1982. 

Deray G, Martinez F, Katlama C, Levaltier B, Beaufils H, Danis M, Rozenheim M, Baumelou A, Dohin E, Gentihni M, et al Foscamet nephrotoxicity mechanism, incidence and prevention. Am J Nephrol 1989 9(4) 316-21. 

Sandler DP, Smith JC. Chronic renal disease risk associated with employment in industries with potential solvent exposure. In Nephrotoxicity mechanisms early diagnosis and therapeutic management. Bach PH, Gregg NJ, Wiks MF, Delacruz L (editors). Marcel Dekker Inc, New York 1991 p 261-266. 

Mudge GH. Analgesic nephropathy renal drug distribution and metabolism. In Nephrotoxic mechanisms of drugs and environmental toxins. Porter GA (editor). Plenum Med Book Co, New York, Eondon 1982 p 209-225. 

Ban M, Flettich D, Fluguet N. Nephrotoxicity mechanism of cis-plantinum (II) diamine dichloride in mice. Toxicol Letters 1994 71 161-168. 

Contribution of established renal cell culture models to the understanding of nephrotoxic mechanisms... 

Beta-lactams such as cephaloridine, cephalothin, cefotiam and imipenem have been associated with nephrotoxicity in humans and experimental animals [9]. An understanding of their nephrotoxicity mechanisms may provide valuable information for elucidation of the biochemical mechanisms of newer p-lactam nephrotoxicity. Similarly to cephaloridine, third- generation cephalosporins such as ceftazidime and cefsulodin and fourth-generation cephalosporins such as cefpirome and cefepime possess a quaternary nitrogen attached to the dihy drothiazine ring which may impart nephrotoxic potential [10]. Clinical and animal studies carried... 

An understanding of how and why chemicals induce nephrotoxicity requires some familiarity with the anatomy and physiology of the kidney. In addition, interpretation of renal toxicology studies will require a working knowledge of the various techniques used for evaluating renal function. It is also important to be aware of which nephrotoxicants require biotransformation before they induce nephrotoxicity, nephrotoxic mechanisms when known, and the site(s) of renal damage for the various nephrotoxicants. 

Dubey C, Bellon B, Kuhn J, et al. 1991b. Increase of a IA expression on B cells during the course of mercury-induced autoimmune disease in Brown Norway rats. In Bach PH, et al., eds. Nephrotoxicity mechanisms, early diagnosis, and therapeutic management. Fourth International Symposium on Nephrotoxicity. New York, NY Marcel Dekker, Inc., 397-400. 

Yasutake, A., Y. Hirayama, and M. Inouye. 1991. Sex Difference of nephrotoxicity by methylmercury in mice. Pp. 389-396 in Nephrotoxicity Mechanisms, Early Diagnosis, and Therapeutic Management. Fourth International Symposium of Nephrotoxicity, Guilford, England, UK, 1989. P.H. Bach, and K.J. Ullrich, eds. New York Marcel Dekker. 

The future holds great promise for unraveling nephrotoxic mechanisms and understanding various aspects of clinical management. To enhance informa hon transfer we decided to pubhsh a CD as a companion to this book. Further into the futiue we plan to develop annual updates to supplement the text information and insure the reader is current in this rapidly evolving field. 

Jennings, R, Koppelstatter, C., Lechner, J., and RfaUer, W. (2008) Renal cell culture models Contribution to the understanding of nephrotoxic mechanisms. In Clinical Nephrotoxins, Springer, New York, pp 223-249. 

Wedeen, R.P., 1982. Lead nephrotoxicity. In Porter, G. (Ed.), Nephrotoxic Mechanisms of Drugs and Environmental Toxins. Plenum Publishing Corp., New York, pp. 255 —265. Wedeen, R.P., 1984. Poison in the Pot The Legacy of Lead. Southern Illinois University Press, Carbondale, IL. 

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