Neosiphonia

D Auria MV, Paloma LG, Minale L, Zampella A, Debitus C, Perez J (1995) Neosiphonia-molide A, a Novel Cyclodepsipeptide, with Antifungal Activity from the Marine Sponge Neosiphonia superstes. J Nat Prod 58 121... 

S-26-Methyl-24-methylenecholest-4-en-3-one has been isolated from the marine fossil sponge Neosiphonia supertes. 

D Auria, M. V., Paloma, L. G., Minale, L., Zampella, A., Debitus, C., and Perez, J., Neosiphoniamolide A, a novel cyclodepsipeptide, with antifungal activity from the marine sponge Neosiphonia superstes, J. Nat. Prod., 58, 121, 1995. 

In a later stage we had the opportunity to investigate in our laboratories other two New Caledonian lithistid sponges, Neosiphonia superstes and Reidispongia coerulea which proved to be a rich source of biological active macrolides and cyclic peptide with unusual structures. 

The first paper on Neosiphonia superstes appeared in literature in 1991 and deals with the isolation of the steroidal compound 109, 25S-25-Methyl-24-methylenecholest-4-en-3-one, with an unconventional side-chain [119],... 

Bioassay guided fractionation of active extracts of Neosiphonia superstes has afforded two more unrelated highly cytotoxic macrolides... 

From the methanolic extract of Neosiphonia superstes, we isolated a new cyclodepsipeptide, neosiphoniaraolide A (121) [129] closely related to... 

Macrolide antibiotic. Isol. from the marine sponge Neosiphonia superstes. Cytotoxic agent. Amorph. solid, [a], +54.1. 

Superstolide A 3, isolated from the New Caledonian sponge Neosiphonia superstes, shows interesting cytotoxicity against malignant cell lines at 4 ng/mL concentration. The key transformation in the synthesis of 3 described J. Am. Chem. Soc. 2008,130, 2722) by William R. Roush of Scripps Florida was the transannular Diels-Alder cyclization of 2, which established, in one step with high diastereocontrol, both the cis decalin and the macrolactone of 3. 

Superstolide is a macrolide isolated from the New Caledonian sponge Neosiphonia superste that shows potent cytotoxic toward several cancer cell lines.Roush and co-workers reported on the total synthesis of (- -)-superstolide that featured a transannular Diels-Alder reaction for preparation of the polycyclic molecular skeleton (Scheme 20.2). " The 24-membered octene 4, prepared by the intramolecular Suzuki coupling of 3,... 

Discodermia, Neosiphonia, Scleritoderma Macrolactones, linear and cyclic peptides, cyclic depsipeptides, phosphorus derivatives, sulfated ceramides... 

Macrohdes may be more complex and contain nitrogen atoms, as is the case for superstolides A and B and sphinxolides B-D, which are highly cytotoxic. These derivatives come from the species Neosiphonia superstes, a deep-... 

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