Nematospiroides dubius

Behnke, J.M., Hannah, J. and Pritchard, D.I. (1983) Nematospiroides dubius vci the mouse evidence that adult worms depress the expression of homologous immunity. Parasite Immunology 5, 397-408. 

Dobson, C. and Tang, J. (1991) Genetic variation and host-parasite relations Nematospiroides dubius in mice. Journal of Parasitology 77, 884-889. 

Dehlawi, M.S., Wakelin, D. and Behnke, J.M. (1987) Suppression of mucosal mastocytosis by infection with the intestinal nematode Nematospiroides dubius. Parasite Immunology 12, 561-566. 

Prowse, S.J., Mitchell, G.F., Ey, P.L. and Jenkin, C.R. (1978) Nematospiroides dubius susceptibility to infection and the development of resistance in hypothymic (nude) BALB/c mice. Australian Journal of Experimental Biology and Medical Science 56, 561—570. 

Williams, D.J. and Behnke, J.M. (1983) Host protective antibodies and serum immunoglobulin isotypes in mice chronically infected or repeatedly immunized with the nematode parasite Nematospiroides dubius. Immunology 48, 37—17. 

The third milestone in the history of the use of fermentation products in agriculture was the discovery of the avermectins. They were first detected in an anthelmintic assay using mice infected with nematospiroides dubius (13). This is one of the few assays in which they could have been detected since they lack antibacterial and antifungal activity. 

The avermectins were initially detected in a program in which thousands of microbial fermentation products were tested in mice for activity against the nematode, Nematospiroides dubius. 

The nematode, Nematospiroides dubius, was selected for the assay. Infected mice were fed for six days with milled Purina Lab Chow which had been mixed with the fermentation product to be tested. The mice were then fed a normal diet and, at 14 days postinfection, fecal pellets were examined for the presence of eggs. If eggs were absent on three successive days, the mice were sacrificed and their small intestines examined for the presence of worms. 

Still other types of activity are claimed for oxadiazole derivatives. For example, compound 131 is an anthelmintic against Nematospiroides dubius in mice, dogs, and sheep.31,210-212 Compound 132 is a local anaesthetic and has antispasmodic and anti-inflammatory activity.205,206,213,214 The sulfa drug 133 is said to be comparable in... 

The drug was ineffective against Nippostrongylus muris, Aspicularis tetraptera, or Nematospiroides dubius in mice and Texas car is leonina in dogs. 

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