Negative regulators, of gene expression

Table 39-1. Effects of positive and negative regulation on gene expression.

Shiio, Y., Yamamoto, T. and Yamaguchi, N. (1992) Negative regulation of Rb expression by the p53 gene product. Proc. Natl. Acad. Sci. USA 89 5206-5210. 

In summary, TFIID is regulated by many factors, with both negative and positive roles. It is the integrated and counterbalanced effects of these factors that control the many important functions of TFIID. This is necessary to achieve a high level of specific regulation of gene expression in vivo. 

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