Gene expression negative regulation

Additional information <1> (<1> 1 mM p-chloromercuribenzoic acid or urea are no inhibitors, MphR(A) is a repressor protein that binds to the promoter of the mph(A) gene and negatively regulates the enzyme expression [3,10]) [3, 10]... 

As these transcription factors regulate the expression of proinflammatory genes, their negative regulation by the GR has become a paradigm for the antiinflammatory and immunosuppressive action of GCs. 

Repression of cspA after acclimation at low temperatures appears to be mediated by the cold box region and is a possible target site for repressor binding [138]. In addition, CspA itself negatively regulates its own gene expression through the cold box [138, 139]. 

Table 39-1. Effects of positive and negative regulation on gene expression.

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