Natural killer T-cells

NKT cells are unique regulatory cells although they also act as effector cells. Their regulatory role is reflected by the pattern of cytokines they secrete, 

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Jahng AW, Maricic I, Pedersen B, et al. Activation of natural killer T cells potentiates or prevents experimental autoimmune encephalomyelitis. J Exp Med 2001 194 1789-1799. 

Acquired Immunodeficiency Syndrome (AIDS) A clinical syndrome due to infection with the RNA human immunodeficiency (retro)virus (HIV) which produces severe immunosuppression (depletion of natural killer T cells), thereby exposing the individual to a variety of opportunistic infections and cancers. 

Akbari 0, Paul JL, Hoyte EG, Berry GJ, Wahlstrom J, Kronenberg M, DeKruyff RH, Umetsu DT CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma. N Engl J Med 2006 354 1117-1129. 

Natural killer T cell NKTcell Subset of T cells, upon activation rapidly release large quantities of cytokines... 

Kronenberg M. Toward an understanding of NKT cell biology progress and paradoxes. Annu. Rev. Immunol. 2005 23 877-900. Zajonc DM, Cantu C 3rd, Mattner J, Zhou D, Savage PB, Bendelac A, Wilson lA, Teyton L. Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. Nature Immunol. 2005 6 810-818. 

Miyamoto K, Miyake S, Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 bias of natural killer T cells. Nature 2001 413 531-534. 

Kaieda S, Tomi C, Oki S, Yamamura T, Miyake S. Activation of invariant natural killer T cells by synthetic glycolipid ligands suppresses autoantibody-induced arthritis. Arthritis Rheum. 2007 56 1836-1845. 

Lu X, Song L, Metehtsa LS, Bittman R. Synthesis and evaluation of an a-C-galactosylceramide analogue that induces Thl-biased responses in human natural killer T cells. ChemBioChem 2006 7 1750-1756. 

Sonoda KH, Exley M, Snapper S, Balk S, Stein-Streilein J (1999) CDl-reacdve natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med. 190 1215-1226. 

Chemical Synthesis of Hormones, Pheromones and Other Bioregulators 6.3.3 KRN7000, a glycosphingolipid that stimulates natural killer T cell... 

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