Natural killer cells therapy

Ushio-Fukai M, Nakamura Y (2008) Reactive oxygen species and angiogenesis NADPH oxidase as target for cancer therapy. Cancer Lett 266 37-52 Valentin A, Rosati M, Patenaude DJ, Hatzakis A, Kostrikis LG, Lazanas M (2002) Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy. Proc Natl Acad Sci U S A 99(10) 7015-7020... 

The potential of immunocytokines was elegantly demonstrated in two separate studies using IL-12 for anti-tmnour therapy. IL-12, a potent stimulator of natural killer cells and cytotoxic T-lymphocytes (CTL), activates the immune system to eradicate the cancer cells. IL-12... 

Mutation in the adenosine deaminase gene on chromosome 20 can cause severe combined immunodeficiency due to absence of T cells, B cells, and natural killer cells (T cell-negative, B cell-negative, natural killer cell-negative autosomal recessive SCID). The lack of the enzyme adenosine deminase results in the accumulation of adenosine and toxic deoxyadenosine nucleotides. The latter can cause apoptosis of lymphocytes. Lymphocyte counts can be as low as 0.5 x 10 /L, affecting primarily T cells which are absent (105). While therapy of missing enzyme has been shown to effect improvement, bone marrow transplantation is the preferred treatment. Milder forms of adenosine deaminase deficiency have been reported (116). 

Whiteside, T. L., Vujanovic, N. L. and Herberman, R. B. (1998). Natural killer cells and tumor therapy. Curr. Top. Microbiol. Immunol. 230, 221-244. 

Interferon type II includes IFN-y, which is probably only produced by T lymphocytes and natural killer cells. IFN-y is of no importance for the therapy of viral hepatitis. (36) (s. p. 702 ) Recently, IFN-o) was isolated, but its biological role is not yet understood. 

Korbelik, M. and Sun, J., Cancer treatment by photodynamic therapy combined with adoptive immunotherapy using genetically altered natural killer cell Hne, Int. J. Cancer, 93, 269, 2001. 

Hall SJ, Sanford MA Atkinson G, Chen SH. Induction of potent antitumor natural killer cell activity by herpes simplex virus-thyntidine kinase and ganciclovir therapy in an orthotopic mouse model of prostate cancer. Cancer Res 1998 58 3221-3225. 

Adult bone marrow-derived stem cells are presently the cell types most widely utilized in cardiac stem cell therapy. A heterogeneous subset, termed autologous bone marrow-derived mononuclear cells (ABMMNCs), is composed of small amounts of stromal or MSCs, HPCs, EPCs, and more committed cell lineages, such as natural killer lymphocytes, T lymphocytes, B lymphocytes, and others [2]. 

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