National Institute for Medical Research Mill Hill

R. Colin Hughes, National Institute for Medical Research, Mill Hill, London, UK... 

A standard preparation of thyrocalcitonin, prepared to the salt-fractionation stage by Method 2 above, is available from the Medical Research Council, Department of Biological Standards, National Institute for Medical Research, Mill Hill, London, and is distributed in ampules containing 0.25 MRC unit. When 0.01 MRC unit is injected intravenously into a 150-g rat, it produces a fall of approximately 10% in the plasma calcium after 50 minutes, i.e., this new unit is approximately 100 times larger than that described by Hirsch et al. (H4) and 1000 times larger than that of Baghdiantz et al. (Bl). From the in-... 

Studies of the binding of antifolate drugs to the enzyme dihydrofolate reductase (DHFR) carried out by Feeney and Roberts and their colleagues at the National Institute for Medical Research (Mill Hill) provide examples of a diverse range of NMR applications. 

London itself became a center of peptide studies. At the National Institute for Medical Research (Mill Hill) the investigations of D.F. Elliot on hypertensin and on bradykinin are mentioned here. At the Postgraduate School of Medicine of the University of London M. Szelke made major contributions in the area of peptide hormones and their antagonists, particularly in the development of novel inhibitors of the angiotensin-renin system. The two dimensional NMR work of W. Gibbons and the X-ray structure studies of T.L. Blundell of biologically active peptides are similarly significant. 

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