Narcotic bowel syndrome

Because of its G1 effects clonidine hydrochloride has been used with some success in a limited number of patients for the management of diarrhea of various etiologies (e.g. narcotic bowel syndrom, idiopathic diarrhea associated with diabetes) (1). 

Tuteja AK, Biskupiak J, Stoddard GJ, Lipman AG. Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain. Neurogastroenterol Motil 2010 22(4) 424-30 e96. 

Choung RS, Locke GR 3rd, Zinsmeister AR, Schleck CD, Talley NJ. Opioid bowel dysfunction and narcotic bowel syndrome a population-based study. Am J Gastroenterol 2009 104(5) 1199-204. 

Gastrointestinal Narcotic bowel syndrome, defined as chronic and/or frequent recurring abdominal pain aggravated by use of narcotics, has been investigated in a random cohort of 4898 people in the community. Narcotic bowel syndrome was rare (n = 5), but those who used narcotics reported more gastrointestinal symptoms and tended to use more laxatives [10 ]. 

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