Clonidine hydrochloride

Clonidine hydrochloride [Catapres, 2-(2,6-dichloroanilino)-2-imidazoline hydrochloride]... 

Procedure Dissolve 0.2 g of clonidine hydrochloride in 70 ml of ethanol (96%) and titrate with 0.1M ethanolic sodium hydroxide Vs determining the end-point potentiometrically. Each ml of 0.1 M ethanolic sodium hydroxide Vs is equivalent to 26.66 mg of C9H9C12,N3, HC1. 

Part—III exclusively treats Electrochemical Methods invariably and extensively used in the analysis of pharmaceutical substances in the Official Compendia. Two important methods, namely potentiometric methods (Chapter 16) deal with various types of reference electrodes and indicator electrodes, automatic titrator besides typical examples of nitrazepam, allopurinol and clonidine hydrochloride. Amperometric methods (Chapter 17) comprise of titrations involving dropping-mercury electrode, rotating—platinum electrode and twin-polarized microelectrodes (i.e., dead-stop-end-point method). 

Sensitization to transdermal clonidine In patients who develop an allergic reaction to transdermal clonidine, oral clonidine hydrochloride substitution may elicit a similar reaction. 

Levinson, M.L. and Johnson, C.E. (1992) Stability of an extemporaneously compounded clonidine hydrochloride oral liquid. Am J Hosp Pharm 49 122-125. 

Clonidine. As with the rationale for P-blockers in the treatment of social phobia, clonidine hydrochloride, an a-adrenergic agonist, has been used in an attempt to target the physiological symptoms of the disorder. In a case report by Goldstein [1987], one subject with social phobia who experienced a primary symptom of blushing was treated with clonidine 0.1 mg twice a day after trials with alprazolam, phenelzine, and propranolol failed to provide symptom relief. The patient reported a dramatic decrease in the frequency and intensity of blushing episodes after 1 week of treatment. At 4-month follow-up, his symptoms remained well controlled and he denied any side effects. 

Knesevich JW Successful treatment of obsessive-compulsive disorder with clonidine hydrochloride. Am J Psychiatry 139 364-365, 1982... 

Centrally acting antiadrenergic agents clonidine hydrochloride methyldopa... 

Clonidine hydrochloride (Catapres), carbamazepine (Tegretol), and methylphenidate (Ritalin) are occasionally useful in intractable cases of migraine. Cyproheptadine (Periactin) may be effective in adults with migraine it is of considerable importance in the treatment of childhood migraine, and many consider it to be the drug of first choice. Dosages range from 4 to 3 mg, three to four times a day, in adults and 4 mg, two to three times a day, in children. 

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