Napsylate

Use in moderate pain Weak analgesic most effective when used with NSAIDs, aspirin, or acetaminophen This drug is not recommended in the elderly Will cause carbamazepine levels to increase 100 mg of napsylate salt = 65 mg of HCI salt Third-line agent for moderate-to-severe pain... 

Levopropoxyphene is the L-isomer of the analgesic agonist dextropropoxyphene. Levopropoxyphene is only mildly antitussive and is rarely used. It has no CNS effects. Side effects include dizziness and nausea. It is available as the napsylate derivative (Novrad) and is taken orally in the form of a liquid or less frequently as a capsule. 

I Brand Name(s) (propoxyphene napsylate) Darvon-N Combinations... 

Mild to moderate pain PO (propoxyphene hydrochloride) 65 mg q4h as needed. Maximum 390mg/day. PO (propoxyphene napsylate) 100 mg q4h as needed. Maximum 600 mg/day. 

Diphenylpropylamine derivatives propoxyphene hydrochloride propoxyphene napsylate... 

Analgesic efficacy and clinical use Dextropropoxyphene (Grover, 1988) is a moderately potent opioid analgesic often combined with paracetamol or acetylsalicylic acid or other NSAIDs (Collins et al., 2000). As the hydrochloride or napsylate it is used orally for the treatment of mild, moderate, or severe pain (Beaver, 1984). 

Dosages and routes of administration Dextropropoxyphene is mostly administered by the oral route. Parenteral injection and rectal administration is painful and induces tissue damage. The ordinary oral doses are 65 mg of the hydrochloride and 100 mg of the napsylate. 

A 76-year-old woman taking lisinopril 20 mg/day and metoprolol for hypertension developed headaches, nausea, and a tingling sensation in her arms. Her serum sodium was 109 mmol/1, with a serum osmolality of 225 mosm/kg, urine osmolality of 414 mosm/kg, and urine sodium of 122 mmol/1. She had taken diclofenac 75 mg/day for arthritic pain for 6 years and naproxen for about 1 month. Propoxyphene napsylate and paracetamol had then been substituted and zolpidem had been started. A diagnosis of SIADH was postulated and thyroid and adrenal causes were excluded. Lisinopril was withdrawn and fluid was restricted to 100 ml/day. The serum sodium gradually corrected to 143 mmol/1. 

I. M. Jalal and S. I. Sa sa, Simultaneous determination of dextro-propoxyphene napsylate, caffeine, aspirin and salicylic acid in pharmaceutical preparations by reversed-phase HPLC, Talanta, 37 1015 (1984). 

Dexchlorpheniramine, 520 Dexchlorpheniramine maleate, 520 Dexedrine, 519 Dexone, 518 Dexpanthenol, 520 Dextroamphetamine sulphate, 519 Dextroamphetamine, 519 Dextroamphetamine phosphate, 519 Dextrodiphenopyrine, 521 Dextrogesic, 522 Dextromethorphan, 520 Dextromethorphan hydrobromide, 520 Dextromoramide, 521 Dextromoramide acid tartrate, 521 Dextromoramide tartrate, 521 Dextrone X, 853 Dextro-pantothenyl alcohol, 520 Dextropropoxyphene, 29,522 Dextropropoxyphene hydrochloride, 522 Dextropropoxyphene napsylate, 522 Dextrorphan, 521, 523 Dextrostix, 1171 Dexuron, 568, 853 Dexylets, 520, 893 Dezone, 518, 519 DF 118, 544... 

Propoxyphene is an analogue of methadone that is widely used as an analgesic. However, single-dose studies have shown that the analgesic properties of propoxyphene are no better than those of placebo. When propoxyphene is used alone in usual analgesic doses (32 to 65 mg of the hydrochloride salt or 50 to 100 mg of the napsylate salt),... 

Propoxyphene Napsylate oral suspension Propoxyphene Napsylate tablets Glass or Stainless Steel, 0.6 M x 3 mm I.D. 3% G2/S1AB Helium 160 FID n-Tricosane USP (24, p. 1425)... 

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