1-Naphthyl glucuronic acid

Roubal et al. (8) applied TLC to the separation and identification of metabolites of l c-iabeled naphthalene administered to coho salmon fingerlings via intraperitoneal injection. 1-Naphthol, a dihydrodiol, mercapturic acid, 1-naphthyl glucuronic acid and a glycoside/sulfate fraction were identified in brain, liver, gall bladder, and muscle 1-naphthol, a dihydrodiol, and 1-naphthyl glucuronic acid were the only metabolites found in heart. 

Mai ins et al. (15) showed by TLC that rainbow trout exposed to l C-labeled naphthalene excrete 1-naphthyl glucuronic acid in the urine almost exclusively. Only 1% of the total radioactivity of the urine was in the form of non-conjugated derivatives. 

Coho salmon naphthalene 1-naphthol 1-naphthyl-glucuronate 1-naphthyl-glucoside mercapturic acid 1-naphthyl sulphate 1,2-dihyroxy-1,2-dihydro-naphthalene... 

The ability of the rat to use lactate, pyruvate, and D-glucose to equal extents in the synthesis of 1-naphthyl D-glucosiduronic acid was demonstrated by Packham and Butler.158 The lactate and pyruvate were labeled with C14 at the carboxyl carbon lactate labeled at Cl and C2 was also used and the D-glucose was uniformly labeled. D-Glucuronate-C14 was utilized for D-glucuronic conjugation on oral administration, but was twenty times as effective after intraperitoneal injection. 

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