Nanostructured materials antibodies

DNA nanostructures have been used to precisely position groups within a material, ranging from proteins, antibodies and antigens, and aptamers to metals and nanoparticles (Figure DNA can also be... 

SWCNT forest electrodes have been employed in electrochemical and electrochemilumines-cent (ECL) immunosensors. Antibody-modified SWCNT forest electrodes and HRP-labeled detection antibodies were first employed to measure the small molecule biotini" and model protein human serum albumini" and later for cancer biomarker proteins in serum. These nanostructured immunosensors offer 3-10-fold gains in sensitivity compared to similar sensors based on flat bulk electrodes.i i Analysis of the SWCNT forest electrode-based sensor revealed that dense packing of the earboxylated ends of SWCNTs enables attachment of a large surface concentration of capture antibodies, whieh, along with other favorable properties of the nanotubes, contributes to the observed sensitivity improvements of SWCNT-modified sensors over sensors based on bulk electrode materials. " ECL-based SWCNT forest immunosensors for eancer biomarker proteins relied on Ru(bpy)3 + encapsulated in silica particles (Section 13.3.6) that were decorated with antibodies.i" " Eor the prostate cancer biomarker prostate-specific antigen, SWCNT forest ECL immunosensors exhibited 34 times higher sensitivities and 10 times lower DLs than analogous... 

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