Structures, nanofibrous

A mixture consisting of aniline ( 0.2 g) and (lS)-(+) camphorsulfonic acid (3.48 g) was dissolved in 10 ml of water and then treated with five separate portions of 0.1 g of ammonium peroxydisulfate dissolved in 1 ml water. Each successive portion was added when the solution turned from blue to green while the reaction mixture was maintained at 20°C. After the additions were completed the mixture was centrifuged and the product washed with water. The circular dichroism spectrum of the product suspensed in water indicated a molar ellipticity of about 90 x 103 deg-cm2/dmol. Transmission electron micrographs showed that the product had a nanofibrous structure with fiber diameters from 30 to 70 nm and had a length of several hundred nanometers. 

Transmission electron micrographs showed that the precipitate was in the form of particles, although some nanofibrous structures were observed. The circular dichroism indicated a molar ellipticity of 5 x 103 deg-cm2/dmol. 

Fig. 2.47 SEM image of a nanofibrous structure of MgH2 synthesized by HCVD [80]...

C.Y. Xu, R. Inai, M. Kotaki, S. Ramakrishna. 2004 Aligned biodegradable nanofibrous structure a potential scaffold for blood vessel engineering. Biomaterials, 25. pp. 877. 

Fig. 17 Images of 3D nanofibrous structure produced by wet-spinning metliod (a). Preosteoblast proliferation on TCP and 3D scaffold (b). ALP activity of preosteoblasts on TCP and 3D scaffolds [147]...

Li WJ et al (2002) Electrospun nanofibrous structure a novel scaffold for tissue engineering. J Biomed Mater Res 60(4) 613-621... 

Methods of Fabricating Aligned Polymer Nanofibrous Structures. 174... 

Cell Interactions with Aligned Nanofibrous Structures. 189... 

Beachley V, Wen X (2010) Polymer nanofibrous structures fabrication, biofunctionalization, and cell interactions. Prog Polym Sci 35(7) 868-892... 

Finally, the investigation of the specifics of the Rehbinder effect (see Chapter IX, 4) in polymer materials, e.g. the formation of nanofibrous structures in the course of polymer... 

Other synthetic polymers that have been utilised in the development of biomedical nanofibrous structures include the nonbiodegradable polyurethane (KhU et al., 2003 Kim et al., 2009 Verreck et al., 2003) and biodegradable polydioxanone (Kalfa et al., 2010). 

Nanofibrous structures have been extensively smdied as the two- or three-dimensional scaffolds that mimic the cell living environment for tissue regeneration. Nanofibrous structures provide temporary spaces with a mnable porosity in which cells can exchange metabolites and nutrients with their environment so that cellular functionality can be maintained, the reconstruction of tissues can be aided, and the tailored mechanical properties will function as desired, and the wound bed can be protected from collapsing, and mechanical mismatch between scaffolds and host tissues can... 

Modification or functionalisalion of nanofibres is the important trend in the development of nanofibrous structures for biomedical applications, in order to engineer specific features that will help maximise their end use performance. A spectrum of bioactive molecules, including antibacterial agents, anti-cancer drugs, enzymes and proteins, can be incorporated into nanofibres via dlHerent approaches. 

The future trend of nanofibre development may include modification toward functionalisation of polymer nanofibres intended to improve their performance and function in biomedical applications. This purpose is achieved by incorporating such therapeutic agents as antibacterial agents and growth factors into the nanofibrous structures, so that the product will duly become capable of infection control, with improved biocompatibility and promotion of cell proliferation and differentiation. 

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