Nanofiber drug delivery systems

TABLE 7.1 Nanofiber drug delivery systems from recent literature... 

Figure 73 Representative 3-D nanostructured scaffolds for bone-specific drug delivery systems, (a) Electrospun sitk scaffold with BMP-2 loaded, scale bar=5 pm (reprinted from Ref. [86] with permission) (b) Self-assembled peptide-amphiphile (PA) nanofibers network, scale bar= 1 mi (reprinted from Ref. [87] with permission) (c) Nanocrystalline apatite modified poly(lactide-co-glycolide) (PLAGA) microsphere scaffolds, scale bar=2pm (reprinted from Ref. [88] with permission) and (d) poly(L-lactic acid) (PLLA) nanofibrous scaffolds incorporated with poly(lactic-co-glycolic acid) (PLGA) nanospheres, scale bar=2 pm (reprinted from Ref. [89] with permission).

Canbolat, M.F., Celebioglu, A., and Uyar, T. (2014) Drug delivery system based on cyclodextrin-naproxen inclusion complex incorporated in electrospun poly capro-lactone nanofibers. Colloids Surf., B, 115, 15-21. 

Kenawy, E., Abdel-Hay, E, El-Newehy, M., and Wnek, G. (2009) Processing of polymer nanofibers through electrospinning as drug delivery systems. Mater. Chem. Phys., 113, 296-302. 

E. (2012) Core/shell nanofibers with embedded liposomes as a drug delivery system. Biomacromolecules, 13, 952-962. 

Gouda, M., Hebeish, A.A., Aljafari, A.I., 2014. Synthesis and characterization of novel drug delivery system based on cellulose acetate electrospun nanofiber mats. Journal of Industrial Textiles 43 (3), 319-329. 

M. Bazhban, M. Nouri, and J. Mokhtari, Electrospinning of cyclodextrin functionalized chitosan/PVA nanofibers as a drug delivery system, Chinese J. of Pol. Sci., 31 (10), 1343-1351,2013. 

Electrospun mats have a larger specific surface area and smaller pore size compared to commercial nonwoven fabrics. They are of interest in a wide variety of applications, including semi-permeable membranes, nanocomposites, filters, protective clothing and biomedical applications such as wound dressings, tissue engineering scaffolds, and drug delivery systems. Recently, unidirectional-like nanofiber mats fabricated by control collector speed were reported and a high mechanical property was obtained. ... 

Meng ZX, Xu XX, Zheng W, Zhou HM, Lia L, Zheng YF, Lou X (2011) Preparation and characterization of electrospun PLGA/gelatin nanofibers as a potential drug delivery system. Colloids Surf B Biointerfaces 84 97-102... 

Rosie et al. [84] discussed the fundamental aspects of the electrospinning process and the properties of nanoflbers, as well as highlighted the enormous potential of nanofibers as drug-delivery systems and tissue scaffolds. As ENMs have high porosity, interconnected open-pore structure, tailorable membrane thickness, and high surface hydrophobicity, they are suitable for MD. 

Nanosized objects perform various functions in the biomedical field. In the human body, nanosized particulate substances behave very differently from larger particles. In 1986, Maeda et al. found that the stained albumin, having a size of several nanometers, naturally accumulates in the region of cancerous tissues, which is now well known as the enhanced permeability and retention (EPR) effect. Many studies in the field of nanoparticles are based on this finding. Another application of nanoparticles is the delivery system using various polyplexes that are composed of carrier molecules and plasmid DNA or nucleic acid drugs such as antisenses and siRNA. In addition, nanofibers are mainly used for biodegradable scaffolds in tissue... 

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