Nanocarriers therapy

PEG-PAsp(DPT) was then applied to construct a nanocarrier of short interference RNA (siRNA), with the ability to show effective RNA interference (RNAi) properties [115]. RNA is extremely unstable against nuclease attack, and thus the establishment of an efficient delivery system is crucial for promoting the RNAi therapy. The complexation behavior of PEG-PAsp(DPT) with siRNA was examined through gel electrophoresis and EtBr exclusion assay to confirm the formation of stable complexes. The free siRNA disappeared at the N/P ratio > 2 in a gel electrophoresis analysis, which was consistent with the result of the EtBr assay where a substantial fluorescence quenching of EtBr was observed at N/P > 2. 

Torchilin VP. Targeted pharmaceutical nanocarriers for cancer therapy and imaging. AAPS J 2007 9 E128-E147. 

Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Danger R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotech 2007 2 751-760. 

One of the most commonly used terms to explain drug targeting is the EPR effect. The porosity and pore size of tumor blood vessels has been amenable to nanocarriers for tumor-targeting therapy, imaging, and diagnosis. The porosity facilitates the supply of adequate nutrients to the developing area in tumors. When tumor growth is inhibited or when the tumor size is decreased by any... 

Kano MR, Bae Y, Iwata C, et al. Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF- beta signaling. Proc Natl Acad Sci 2001 , 104 3460-3465. 

Cinteza LO, Ohulchanskyy TY, Sahoo Y, et al. Diacyllipid Micelle-Based Nanocarrier for Magnetically Guided Delivery of Drugs in Photodynamic Therapy. Mol Pharm 2006 3 415-423. 

Parnami N, Garg T, Rath G, Goyal AK. Development and characterization of nanocarriers for topical treatment of psoriasis by using combination therapy. Artif Cells Nanomed Biotechnol. 42(6) (2014) 406-412. 

Dutta R. K., Sahu S. (2012c). Development of oxaliplatin encapsulated in magnetic nanocarriers of pectin as a potential targeted drug delivery for cancer therapy. ResuIti hanrhSa., 2, 38-45. 

One of the most important properties of chitosan is its antitumor activities for cancer therapy. Chitosan is reported to cause apoptosis and cancer cell cytotoxicity through caspase-3 activation. This property has been demonstrated on different tumor cells such as bladder, breast and colon cancer cells in different studies. Chitosan also has immunoadjuvant effects. It has been shown to stimulate macrophages and polymorphonuclear cells, thus inhibiting tumor cell proliferation. Thanks to these properties, chitosan has been extensively studied as a polymer for nanocarriers for decades. 

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