Nanocapsules solvent displacement

Fessi H, et al. Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int J Pharm 1989 55 R1. 

V. C. F. Mosqueira, et ah. Poly (D, L-lactide) nanocapsules prepared by a solvent displacement process Influence of the composition on physicochemical and structural properties. Journal of Pharmaceutical Sciences, 89(5), 614-626 (2005). 

Keywords Nanocapsules, nanospheres, polymer nanoparticles, confined impinging jets mixer, vortex mixer, flash nanoprecipitation, solvent displacement, freeze-drying, lyoprotectants,... 

H. Fessi, J.P. Puisieux, N. Devissaget, N. Ammoury, and S. Benita, Nanocapsule formation by interfacial polymer deposition following solvent displacement. International Journal of Pharmaceutics, 55 (1), R1-R4,1989. 

Valente, B. Stella, D.L Marchisio, F. Dosio, and A.A. Barresi, Production of PEGylated nanocapsules through solvent displacement in confined impinging jet mixers. Journal of Pharmaceutical Science, 101 (7), 2490-2501, 2012. 

Nanocapsules act like a reservoir, which are called vesicular systems. They carry the active substance entrapped in the solid polymeric membrane or on their surfaces. The cavily inside contains either oil or water. A schematic diagram of Polymer Nanocapsules is shown in Fig. 9.2 [5], There are different methods that are used nowadays to prepare polymeric nanoparticles, such as nanoprecipitation (also termed as the solvent diffusion and solvent displacement method), solvent evaporation, dialysis, microemulsion, surfactant-free emulsion, salling-out, supercritical fluid technology, and interfacial polymerization [2]. Among these methods, nanoprecipitation is a fast and simple process, which does not require a pre-prepared polymer emulsion before the nanoparticle preparation. It produces a dispersion of nanoparticles by precipitation of preformed hydrophobic polymer solution. Under... 

---