Naltrexone hydrochloride

Naltrexone hydrochloride dihydrate (l-7V-cyclopropylmethyl-7,8-dihydro-14-hydroxy-morphinan-6-one hydrochloride) [16676-29-2] M 413.9, m 274-276°, [a] -173° (c 1, H2O), pKEst(i) 6 (N-cyclopropylmethyl), pKEst(i) (phenolic OH). This narcotic antagonist has been purified by recrystn from MeOH and dried air. The free base has m 168-170° after recrystn from Me2CO. [Cone et al. J Pharm Sci 64 618 7975 Gold et al. Med Res Rev 2 211 7952.]... 

TO MEDICAL PERSONNEL TREATING ME IN AN EMERGENCY This patient is taking the oral opioid antagonist reVia , formerly known as Trexan (naltrexone hydrochloride). 

Willemsen-Swinkels, S.H.N., Buitelaar, J.K., Nijhof, G., and Van Engeland, H. (1995a) Failure of naltrexone hydrochloride to reduce self-injurious and autistic behavior in mentally retarded adults. Double-blind placebo-controlled studies. Arch Gen Psychiatry 52 766-773. 

Mitchell JE, Christenson G, Jennings J, et al. A placebo-controlled, double-blind cross-over study of naltrexone hydrochloride in outpatients with normal weight bulimia. J Clin Psychopharmacoi 1989 9 94-97. 

Naltrexone hydrochloride dihydrate (17-[cyclopropylmethyl]-4,5-epoxy-3,14-dihydroxy-... 

Naloxone (Narcan) and naltrexone hydrochloride (Trexan) reverse the respiratory depressant action of narcotics related to morphine, meperidine, and methadone. They differ from other narcotic analgesics in several respects. Naloxone does not cause respiratory depression, pupillary constriction, sedation, or analgesia. However, it does antagonize the actions of pentazocine. Naloxone neither antagonizes the respiratory depressant effects of barbiturates and other hypnotics nor aggravates their depressant effects on respiration. Similar to nalorphine, naloxone precipitates an abstinence syndrome when administered to patients addicted to opiate-like drugs. 

Design of controlled release inert matrices of naltrexone hydrochloride based on percolation concepts, Int. J. Pharm., 181, 23-30. 

A 44-year-old physically healthy woman developed auditory and visual hallucinations and persecutory delusions. She had been given naltrexone hydrochloride 50 mg/day 3 days before the acute psychotic incident in order to prevent relapse of alcohol dependence. Her psychotic symptoms completely resolved 48 hours after withdrawal of naltrexone. 

Infra-red Spectrum. Principal peaks at wavenumbers 1716,1505, 1280, 1639, 1115, 909 (naltrexone hydrochloride, KBrdisk). 

Hydroquinidine Hydrochloride Normorphine Debrisoquine Sulphate T richlormethiazide Naltrexone Hydrochloride Oxycodone Hydrochloride Biperiden Hydrochloride Hydralazine Hydrochloride Levodopa... 

The release of the narcotic antagonist, naltrexone hydrochloride, from the internal aqueous phase of a w/o/w emulsion was found (7/ to decrease with a value of D of 1 x 10 cm s-l with... 

Naltrexone hydrochloride is anarcotic antidote. It is an opioid receptor antagonist, markedly attenuating or completely blocking, reversibly, the subjective etfects of fV-administered opioids. It is indicated in the treatment of alcohol dependence and as a blockade of exogenously administered opioids. 

Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol and/or opioid dependence. It is marketed in generic form as its hydrochloride salt, naltrexone hydrochloride, and sold under the trade names Revia and Depade. Naltrexone and its active metabolite 6-p-naltrexol are competitive antagonists at p- and K-opioid receptors, and to a lesser extent at 8-opioid receptors [5]. Naloxone is a drug used to counter the effects of opioid... 

Drug fonnniations Naltrexone hydrochloride precipitated severe opioid withdrawal in a 39-year-old woman with a history of chronic pain who instead of methadone 160 mg/day was given Embeda, a new product combining morphine sulfate 30 mg extended release with naltrexone 1.2 mg, intended to reduce the abuse potential of morphine [215 ]. She chewed the tablet, instead of swallowing it, releasing the naltrexone. 

Stauffer J, Setnik B, Sokolowska M, Romach M, Johnson F, Sellers E. Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users a randomized, double-blind, placebo-controlled, crossover study. Clin Drug Invest 2009 29(12) 777-90. 

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