N-succinyl-chitosan

Reductive amination of AT-succinyl chitosan and lactose using sodium cyanoborohydride in a phosphate buffer (pH 6.0) for 6 days was suitable for the preparation of lactosaminated M-succinyl chitosan (Fig. 3). Over 10% of dose/g-tissue was distributed to the prostate and lymph nodes at 48 h postadministration in both chitosan and lactosaminated N-succinyl chitosan. The labeled lactosaminated M-succinyl chitosan was easily distributed into not only the liver but also prostate, intestine, preputial gland and lymph nodes [153]. 

Kato Y, Onishi H, Machida Y (2000). Evaluation of N-succinyl-chitosan as a systemic long-circulating polymer. Biomaterials. 21 1579-1585. 

Song, Y., Qnishi, H. and Nagai, T., Synthesis and drug-release characteristics of the conjugates of mitomycin C with N-succinyl-chitosan and carbox5nnefhyl-chitin, Chem. Pharm. Bull., 40(10), 2822, 1992. 

Kato, Y, Onishi, H., and Machida, Y. (2001). Biological characteristics of lactosaminated N-succinyl-chitosan as a liver-specific drug carrier in mice,/. Control Release, 70,295-307. 

Kamiyama, K., Onishi, H., Machida, Y. (1999). Biodisposition characteristics of N-succinyl-chitosan and glycol-chitosan in normal and tumorbearing mice, Biol Pharm. Bull.. 22(2), 179-186. 

Luo H, Su H, Wang X, Wang L, Li J. N-Succinyl-chitosan nanoparticles induced mitochondria-dependent apoptosis in K562. Mol CeU Probes. 2012 26(4) 164-9. 

Luo H, li J, Chen X. Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells. Biomed Pharmacother. 2010 64(8) 521-6. 

H. Onishi, Y. Machida, and K. Kamiyama, Pharmacokinetics and tissue distribution properties of glycol-chitosan and N-succinyl-chitosan in mice, in Proceedings of the Controlled Release Society, pp. 645-646,1996. 

Yan, C., Chen, D., Gu, J. etal. Preparation of N-succinyl-chitosan and their physical-chemical properties as a novel excipient. The Pharmaceutical Society of Japan. 2006, v. 126, 789-793. 

Mura, C., Manconi, M., Valenti, D., et al. In vitro study of n-succinyl chitosan for targeted dehvery of 5-aminosalicylic acid to colon. Carbohydrate Polymers. 2011, V. 85. Iss. 3,578-583. 

Lu B, Sun Y, Li Y et al (2009) N-succinyl-chitosan grafted with low molecular weight polyethylenimine as a serum-resistant gene vector. Mol Biosyst 5 629-637... 

Zhu AP, Chtai T, Yuan LH et al (2006) Synthesis and characterization of N-succinyl-chitosan and its self-assembly of nanospheres. Carbohyd Poiym 66 274—279... 

To separate Cu (II) ions from multi-element coexistence solution, Sun et al. synthesized a new adsorbent material [32]. N-Succinyl chitosan (NSC) synthesized via introduction of succinyl groups at the N-position of the glucosamine units of chitosan. NSC was added into the copper acetate solution to form the Cu (II) template NSC. After crosslinking, the crosslinked NSC resins with Cu (II) as template ions were obtained. The results of the adsorption experiments showed that the crosslinked NSC template can selectively adsorbed Cu (II) ions from the solution of Cu (II), Zn (II), Co (II), and Ni (II) ions coexistence. The crosslinked NSC template also showed a good reusability. After reuse for eight times, the adsorption capacity of the crosslinked NSC template for Cu (II) ions decreased slightly from 2.11 to 1.88 mmol/g. 

Sun, SL Wang, Q Wang, AQ. Adsorption properties of Cu (II) ions onto N-sucdnyl-chitosan and crosslinked N-succinyl-chitosan template resin. Biochemical Engineering Journal, 2007, 36, 131-138. 

Kumar, R., Isloor, A. M., Ismail, A. R, and Matsuura, T. 2013a. Performance improvement of polysulfone ultrafiltration membrane using N-succinyl chitosan as additive. Desalination 318 1-8. 

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