N-methyl-D-aspartic acid

Grb-2 facilitates the transduction of an extracellular stimulus to an intracellular signaling pathway, (b) The adaptor protein PSD-95 associates through one of its three PDZ domains with the N-methyl-D-aspartic acid (NMDA) receptor. Another PDZ domain associates with a PDZ domain from neuronal nitric oxide synthase (nNOS). Through its interaction with PSD-95, nNOS is localized to the NMDA receptor. Stimulation by glutamate induces an influx of calcium, which activates nNOS, resulting in the production of nitric oxide. 

Jacocks, H.M. and Cox, B.K., Serotonin-stimulated [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine, J. Pharmacol. Exp. Ther., 262, 356, 1992. 

H. Yokoyama, N. Mori, N. Kasai, T. Matsue, I. Uchida, N. Kobayashi, N. Tsuchihashi, T. Yoshimura, M. Hiramatsu, and S.I. Niwa, Direct and continuous monitoring of intrahippocampal nitric oxide (NO) by an NO sensor in freely moving rat after N-methyl-D-aspartic acid injection. Denki Kagaku 63, 1167-1170 (1995). 

The main building block of PEDC (1 -phenyl-2-[(S)-l-aminoethyl] -N,N -di-ethylcyclopropanecarboxamide), a potent NDMA (N -methyl-D-aspartic acid) receptor antagonist of a cyclopropane structure, N -benzyl-C-cyclopropyl nitrone... 

Ahmed, M . S., Mather, A., Enna, S. J. Binding of pHJdesglycinyl remacemide to rat brain membranes association with the benzomorphan attachment site of the N-methyl-D-aspartic acid receptor channel, Brain Res. 1999, 8, 46-50. 

Eide, P. K., Jorum, E., Stubhaug, A., Bremmes, J., Breivik, H. Relief of post-herpetic neuralgia with the N-methyl-D-aspartic acid receptor antagonist ketamine a double-blind, cross-over comparison with morphine and placebo, Pain 1994, 58, 347-354. 

Kleckner, N. W. and Dingledine, R. Requirement for glycine in activation of N-methyl-D-aspartic acid receptors expressed in Xenopus oocytes, Science 1988, 241, 835-837. 

Salituro, F. G., Harrison, B. L., Baron, B. M., Nyce, P. L., Stewart, K. T., Kehne, J. H., White, H. S., McDonald, I. A. 3-(2-Carboxyindol-3-yl)propionic acid-based antagonists of the N-methyl-D-aspartic acid receptor associated glycine binding site, J. Med. Chem. 1992, 35, 1791-1799. 

Dracheva S, Marras SA, Elhakem SL, Kramer FR, Davis KL, et al. 2001. N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia. Am J Psychiatry 158 1400-1410. 

C5H8N20 1H-imidazole-1-ethanol 1615-14-1 25.00 1.0826 2 5252 C5H9N04 N-methyl-D-aspartic acid 6384-92-5 20.00 1.5120 2... 

Apoptotic/necrotic transformation of excitable cells. Effects of dipeptides directed to support stability of cellular structures increase the reliability of cellular functions under normal conditions and especially during oxidative stress, which accompanies effect of several extreme factors. It was found in experiments on individual neurons that carnosine prevents cell death induced by excitotoxic compounds, N-methyl-D-aspartic acid (NMDA) or kainate [93-95] or experimental hypoxia/reoxigenation [96]. Apoptosis induced by exposure of cerebellum neurons to kainic acid (see Table 6), was arrested if the cells were pre-incubated with carnosine or anserine and simultaneously heavy necrotic processes were substitute by light (reversible) necrosis. At the same time, N-acetylcamosine or homocaraosine did not reveal protecting action [94,95]. 

Figure 10.9. Biophysical properties of the N-methyl-D-aspartic acid receptor. The current voltage (i/v) relationship measured in physiological solutions shows a region of negative slope conductance at hyperpolarized potentials. Little inward current is observed until the cell is substantially depolarized. However, when Mg + is removed from the bathing medium the i/v relationship follows Ohm s law and is represented by a straight line. The reason for this behavior is that Mg + block NMDA receptors in a voltage dependent manner (see main text).

Kessler M, Terramani T, Lynch G, Baudry M (1989) A glycine site associated with N-methyl-D-aspartic acid receptors Characterization and identification of a new class of antagonists. J Neurochem 52 1319-1328. 

Stanley, B. G., L. H. Ha, L. C. Spears and M. G. Dee, 2nd (1993). Lateral hypothalamic injections of glutamate, kainic acid, D,L-alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid or N-methyl-D-aspartic acid rapidly elicit intense transient eating in rats. Brain Res 613(1) 88-95. 

Krogsgaard-Larsen, P, Ferkany, J. W., Nielsen, E. O., Madsen, U., Ebert, B., Johansen, J. S., Diemer, S. H., Bruhn, T, Beattie, D. T, Curtis, D. R. Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection. J. Med. Chem. 1991,54,123-130. 

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