N-Carboxymethylation

Chemical Name N,N -1,2-Ethanediylbis[N-(carboxymethyl)glycine] -disodium ssit Common Name EDTA disodium Structural Formula NaOOCCH2... 

N-(Heptafluor-propyl)- -athylester 130 N-(2-Methoxycarbonyl-athyl)- -athylester 675 N-Methyl-N-carboxymethyl- -methylester 130 N-Methyl-N-phenyl- -methylester 130 N-Methyl-N-thienyl-(2)- -methylester 129 N-(2,2,3,3,3-Pentafluor-propyl)- -athylester 130 N-(Perfluor-alkyl)- -ester 132 N-(2-Phenyl-athyl)- -methylestcr 132 N-Phenyl- -methylester 128f. N-(/J-r>-Ribofuranosyl)-N-(3-hydroxy-propyl)- 140 N-Undecyl- -methylester 130... 

Co-administration of ofloxacin and chitosan in eyedrops increased the bioavailabUity of the antibiotic [290]. Trimethyl chitosan was more effective because of its solubility (plain chitosan precipitates at the pH of the tear fluid). On the other hand, N-carboxymethyl chitosan did not enhance the corneal permeability nevertheless it mediated zero-order ofloxacin absorption, leading to a time-constant effective antibiotic concentration [291]. Also W,0-carboxymethyl chitosan is suitable as an excipient in ophthalmic formulations to improve the retention and the bioavailability of drugs such as pilocarpine, timolol maleate, neomycin sulfate, and ephedrine. Most of the drugs are sensitive to pH, and the composition should have an acidic pH, to enhance stability of the drug. The delivery should be made through an anion exchange resin that adjusts the pH at around 7 [292]. Chitosan solutions do not lend themselves to thermal sterilization. A chitosan suspension, however. 

Chloro-l,2-benzenediamine gave 6-chloro-2,3(l//,47/)-quinoxalinedione (258) [neat (C02Et)2, reflux, 16 h 98%] also some analogsJ 3-(A-Carboxymethyl-A-methylamino)-4-ethyl-1,2-benzenediamine gave 5-(N-carboxymethyl-A-methylamino)-6-ethyl-2,3(l//,47/)-quinoxalinedione (259) [(C02Me)2, EtOH, reflux, 16 h 45%]. ... 

Numerous substituted derivatives of chitin and chitosan are known [67] some important examples are shown in Scheme 10.9. The possibility of forming either anionic (5,7,8,11) or cationic (9,12) derivatives should be noted. The O-carboxymethyl (5) and N-carboxymethyl (11) polymers are of particular interest as they have stronger complex-forming capabilities with metal ions than either unsubstituted chitosan or EDTA [65]. In practice, derivatives formed by substitution via the 2-amino group of chitosan are more common than those substituted via the 6-hydroxy position of the glucopyranose grouping [65]. 

Furthermore, attempted cyclization of N-carboxymethyl meroquinene ethyl ester failed to afford any of the enone, suggesting that the carboxylic acid was an intermediate. The N-protecting groups, in addition to benzoyl, that are tolerated include CC Me, pivaloyl, acetyl, toluenesulfonyl, CBz, and alkyl. 

Tetrakis(triphenylphosphine)palladium(0) Palladium, tetrakis(triphenylphosphine) (8) Palladium, tetrakis(triphenylphosphine)-, (T-4)- (9) (14221-01-3) Ethylenediaminetetraacetic acid, tetrasodium salt , Glycine, N,N -1,2-ethanediylbis[N (carboxymethyl)-, tetrasodium salt, trihydrate (9) (67401-50-7)... 

Dunn JA, Ahmed MU, Murtiashaw MH, Richardson JM, Walla MD, Thorpe SR and Baynes JW (1990) Reaction of ascorbate with lysine and protein under autoxidizing conditions formation of N-(carboxymethyl)lysine by reaction between lysine and products of autoxidation of ascorbate. Biochemistry 29, 10964-10970. 

Slight SH, Prabhakaram M, Shin DB, Feather MS and Ortwerth BJ (1992) The extent of N-(carboxymethyl)lysine formation in lens proteins and polylysine by the autoxidation products of ascorbic acid. Biochim Biophys Acta 1117, 199-206. 

Fig. 6. The structure of the anion of 4D, [Fe402(OH)2(5-MeHXTA)2) . 5-MeHXTA stands for N,N -(2-hydroxy-5-methyl l,3-xylylene)bis(N-(carboxymethyl) glycine). Only the Iron coordination spheres are shown. (Reproduced from Ref. 10a. Copyright 1988 American Chemical Society.)...

Ethylenediaminetetraacetic acid, tetrasodium salt Glydne, N,N -1,2-ethanediylbis[N-(carboxymethyl)]-, tetrasodium salt, trihydrate (67401-50-7), 65, 166... 

Die Cyclisierung der oc-Guanidino-carbonsauren fiihrt zu2-Amino-4-hydroxy-imidazolen. Nach dieser Methode crhalt man z. B. durch Erhitzen von N -Carboxymethyl-N -methyl-gua-nidin (Kreatin) in Salzsaure in 80% Ausbeute 2-Amino-4-hydroxy-I-methyl-imidazol (Kreati-ninf61 ... 

Cancer-risk-diet relationship, 262 Canonical correlation analysis, 104 Capsaicin, 15-16 N-(Carboxymethyl)chitosan, preservation of meat flavor, 73 Carrageenan, fat replacement in ground beef, 73-75 Carry-over, description, 57 Carry-through, description, 57 Carvone, headspace analysis, 24,25/ L-Carvone, chemicals resulting in anosmias, 211... 

Snyder et al.7S bound N-carboxymethyl-L-valine to a styrene-divinylbenzene copolymer 35 and used its Cu complex to resolve racemic amino acids. With all... 

IRON COMPOUNDS] (Vol 14) N,Ny-l,2-Ethanediylbis(N-(carboxymethyl)-glycinato]ferrate(2-)... 

Chemical Name Glycine, N-(2-((2-benzoyl-4-chlorophenyl)amino)-2-oxoethyl)-N-(carboxymethyl)... 

A round bottom flask is charged with dimethylformamide 72.0 g, acetic anhydride 25.0 g, pyridine 2.0 g, and nitrilotriacetic acid (NTA) 38.2 g and the suspension is nitrogen purged for several minutes. The flask is stoppered and the mixture is stirred at room temperature for 3 days. A small amount of unreacted NTA is filtered out. The bulk of the solvent 79 ml is removed in vacuo at a bath temperature of 60°-70°C. The resulting viscous solution is twice roto-vacued after two successive additions of 40 ml dimethylformamide. So the 2,6-diketo-N-carboxymethyl morpholine (NTA anhydride) is prepiared. 

N-(Carboxymethyl)-1-amino-l-desoxyfructose. The Amadori rearrangement is catalyzed by the amino acid carboxyl moiety. 

Di Colo, G, Zambito, Y., Burgalassi, S., and Saettone, M. F. (2003), Effects of chitosan and of its N-trimethyl and N-carboxymethyl derivatives on the ocular pharmacokinetics of ofloxacin in rabbits, paper presented at the 30th International Symposium on Controlled Release of Bioactive Materials, Glasgow, Scottland. 

---