Pharmacokinetics ocular

CH Chiang, RD Schoenwald. (1986). Ocular pharmacokinetic models of clonidine-3H hydrochloride. J Pharmacokin Biopharm 14 175-211. 

The experimental methods for evaluating the BRB transport in vivo and the ocular pharmacokinetics of systemic drug administration are relatively straightforward and have been in use for over two decades. Overall, they are useful as a guide for the selection of drug candidates for the treatment of retinal diseases. With the combined use of conventional in vivo methods and newly developed... 

S. Macha and A. K. Mitra. Ocular pharmacokinetics in rabbits using a novel dual probe microdialysis technique. Exp. Eye Res. 72 289-299 (2001). 

Maurice, D. M., and Mishima, S. Ocular pharmacokinetics. In Handbook of Experimental Pharmacology Pharmacology of the Eye, Vol. 69, Berlin Springer-... 

Di Colo, G, Zambito, Y., Burgalassi, S., and Saettone, M. F. (2003), Effects of chitosan and of its N-trimethyl and N-carboxymethyl derivatives on the ocular pharmacokinetics of ofloxacin in rabbits, paper presented at the 30th International Symposium on Controlled Release of Bioactive Materials, Glasgow, Scottland. 

It has been reported in an ocular pharmacokinetic study of cyclosporin A incorporated in deoxycholic acid-based anionic and stearylamine-based cationic emulsions in rabbit that, when compared to anionic emulsion, the cationic emulsion showed a significant drug reservoir effect of more than 8 h in corneal and conjunctival tissues of the rabbit eye following topical application [106], Since cornea and conjunctiva are of anionic nature at physiological pH [107], the cationic emulsion would interact with these tissues electrostatically to implicate the observed cyclosporin A reservoir effect. This hypothesis is supported, in principle, by an ex vivo study which showed that cationic emulsion carrier exhibited better wettability properties on rabbit cornea than either saline or anionic emulsion carrier [108],... 

Tang-Liu, D. D., and Acheampong, A. (2005), Ocular pharmacokinetics and safety of ciclosporin, a novel topical treatment for dry eye, Clin. Pharmacokinet.,44,247-261. 

Manrice DM, Mishima S. Ocular pharmacokinetics. In Sears ML, ed. Pharmacology of the eye handbook of experimental pharmacology, vol. 69. Berlin Springer-Verlag, 1984 19-116. 

Urtti A. ChaUenges and obstacles of ocular pharmacokinetics and dmg delivery. Adv Dmg DeUv Rev 2006 July 31. 

Side effects associated with use of topical tretinoin ointment include transient hyperemia, irritation, or burning. Ocular pharmacokinetic studies in rabbits show low levels of drug in the aqueous humor after topical application of [ H]-tretinoin, with major tissue uptake in the surface epithelium and the iris. Because retinoic acid has poor stability in the presence of light and oxygen and is insoluble in water, its formulations and clinical use are limited. Although it is capable of reversing squamous metaplasia and keratinization, these ocular surface changes are seen only in severe, not mild to moderate, cases of dry eye. 

Tissie G, Sebastian G, Elena PP, Driot JY, Trinquand C. Alginic acid effect on carteolol ocular pharmacokinetics in the pigmented rabbit. Ocul Pharmacol Ther 2002 18(1) 65-73. 

Chien DS, Schoenwald RD. Ocular pharmacokinetics and pharmacodynamics of phenylephrine and phenylephrine oxazoli-dine in rabbit eyes. Pharm Res 1990 7 476-483. 

Most studies on ocular pharmacokinetics and dmg bioavailability have been carried out in non-equine species, and much of current clinical... 

Schoenwald RD. Ocular pharmacokinetics/pharmacodynamics . In Mitra AK, ed. Ophthalmic Drag Delivery Systems. New York Marcel Dekker, Inc., 1993 83-110. 

Table 9.7 Ocular pharmacokinetics of dexamethasone in various formulations...

Urtti, A. (2006) Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv. Drug. Deliv. Rev., 58, 1131-1135. 

Driot JY, Novack G, Rittenhouse K, Milazzo C, Pearson PA. Ocular pharmacokinetics of fluocinolone acetonide after Retisert intravitreal implantation in rabbits over a 1-year period. J Ocul Pharmacol Ther 2004 20(3) 269-270. 

Mannermaa, E. Vellonen, K.S. Urtti, A. Drug transport in corneal epithelium and blood-retina barrier Emerging role of transporters in ocular pharmacokinetics. Adv. Drug Deliv. Rev. 2006, 58 (11), 1136-1163. 

Chetoni, P. Rossi, S. BurgalassL S. Monti, D. Mariotti, S. Saettone, M.F. Comparison of liposome-encapsulated acyclovir with acyclovir ointment Ocular pharmacokinetics in rabbits. J. Ocul. Pharmacol. Then 2004, 20 (2), 169-177. 

NCJ Bauer, M Motamedi, JP Wicksted, WF March, CA Webers, F Hendrikse. Non-invasive assessment of ocular pharmacokinetics using confocal Raman spectroscopy. J Ocul Pharmacol Ther 15 123-34, 1999. 

The main subjects to be covered at our 4th Congress here in Annecy are "Electrophysiology of the eye" and "Ocular Pharmacokinetics". I warmly welcome our invited speakers, very experienced and renowned colleagues, who will update our knowledge in both the clinical and preclinical aspects of these fields ... 

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