Myocarditis shock

Trials of the effects of endothelin receptor antagonists in patients with heart failure, coronary artery disease, arterial hjtpertension, and pulmonary hjtpertension have been reviewed (6), as have their uses in treating cancers (7) and cerebral vasospasm (8), and their potential uses in atherosclerosis, re-stenosis, myocarditis, shock, and portal hypertension (9)... 

Acute myocarditis and depression of myocardial contractility following cardiac arrest and prologed cardiac surgery also the causes of cardiogenic shock. 

Allergic reactions to tetracyclines are less than half as common as allergic reactions to penicillin. For this reason, tetracyclines are alternatives in patients with allergic reactions to other antibiotics. Exceptional observations of anaphylactic shock have been reported (37,38). In a few cases tetracychnes were assumed to be the cause of hypersensitivity myocarditis (39). Pneumonitis with eosinophiha has been described in association with tetracychnes (40). A serum sickness-hke syndrome was probably associated with minocycline in a 19-year-old man treated for acne (41). Allergic and toxic reactions may in some cases have been caused by degraded formulations or additives (42). Tumor-inducing effects have not been reported. 

Adverse reactions to penicillins are rare diarrhoea can occur due to alteration in normal gastrointestinal bacteria. In fact, penicillins are probably the least toxic drugs known. Hypersensitivity reactions to penicillins occur in up to 10% of patients and vary from mild skin rashes to exfoliative dermatitis and Stevens-Johnson syndrome (immune vasculitis with arthritis, nephritis, central nervous system abnormalities and myocarditis) and from bronchoconstriction to life-threatening anaphylactic shock. 

In a case of acute hypersensitivity myocarditis secondary to carbamazepine, diagnosed post-mortem, there was diffuse infiltration of the myocardium by eosinophils and ljmiphocj4 es, with myocyte damage death was due to cardiogenic shock [110 ]. 

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