Myoblasts mononuclear

Skeletal myoblasts are adult, tissue-specific stem cells [73] located between the basal lamina and the sarcolemma on the periphery of the mature skeletal-muscle fiber [74]. Also known as muscle satellite cells, these small, mononuclear cells are activated by biochemical signals to divide and differentiate into fusion-competent cells after muscle injury. 

Thompson et al. (30) Rabbit Cryoinjury Skeletal myoblasts vs. bone marrow mononuclear cells No difference between SKMB and mononuclear bone marrow stem cells regarding LV function... 

Abbreviations BM-MNC. tone marrow mononuclear cell CF. cardiac fibroblast CM, cardiomyocyte FB. fibroblast LAD. left anterior descending artery LV, left ventricle SKMB, skeletal myoblast. 

Abbreviations BM-MNC, bone marrow mononuclear cell CABO, coronary artery bypass grafting CPC, circulating progenitor cells LV. left ventricle LVED. left ventricular end-diastolic diameter LVEDV, left ventricular end-diastolic volume LVEF, left ventricular ejection fraction NYHA, New York Heart Association SKMB, skeletal myoblast. 

In contrast to that of myoblasts and mesenchymal cells, BM mononuclear or EPC delivery is primarily intracoronary (9), Presumably owing to the much smaller size of these angiogenic cells, their delivery has not been associated with significant adverse ischemic events, However, BM cell delivery has been associated with the theoretical potential for angiogenesis at unwanted sites, such as in occult tumors or retina, This unanticipated and potentially serious consequence illustrates our need to learn from our previous gene therapy colleagues and to expect the unexpected in this field,... 

The process of human muscle regeneration is just a repeated process of muscle embryonic development (Figure 45. lA). The earliest myogenic precursors in this development are mononuclear myoblasts. These still monunucleated but... 

A) Stages of muscle development from mononuclear myoblast to the mature innervated myofiber. Nuclei, which are still centrally located in myotubes, move to the periphery in the mature fiber as a result of the synthesis of contractile elements in the sarcoplasm. Mature fibers contract and exhibit cross-striations. Only mononuclear myoblasts still have the capacity to divide and proliferate. Some of them do not fuse and become entrapped as mononuclear satellite cells under the basal lamina of the mature fiber. (B) Reproduction of this process in the experimental model of the in vitro innervated human muscle axons are labeled by arrows and functionally innervated myotubes by arrowheads. Cross-striations could be seen in the innervated myotubes at higher magnification (insert). 

The Effect of DFP on IL 6 Secretion from the Mononuclear Myoblasts and Myotubes... 

---